Cell culture bioprocessing - the road taken and the path forward.

Curr Opin Chem Eng

Department of Biomedical Engineering and Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455-0132 USA.

Published: December 2020

Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773285PMC
http://dx.doi.org/10.1016/j.coche.2020.100663DOI Listing

Publication Analysis

Top Keywords

cell culture
12
cell
5
culture bioprocessing
4
bioprocessing road
4
road path
4
path forward
4
forward cell
4
culture processes
4
processes produce
4
produce vast
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!