AI Article Synopsis
- Idiopathic pulmonary fibrosis is a serious lung disease with no known cause, and antifibrotic drugs like pirfenidone are used for treatment, although they can have significant side effects for some patients.
- Researchers hypothesized that a low-dose form of pirfenidone delivered directly into the lungs could be just as effective as higher doses taken orally.
- The study found that low-dose intranasal pirfenidone provided similar improvements in lung conditions as high-dose oral pirfenidone, suggesting it could be a powerful treatment option with potentially fewer side effects.
Article Abstract
Idiopathic pulmonary fibrosis is a chronic, progressive, and lethal lung disease of unknown etiology. Antifibrotic drugs, including pirfenidone, are currently used for the treatment of the disease. The oral administration of pirfenidone is an effective therapy, as demonstrated by several clinical trials, although it causes severe adverse events in some patients. We hypothesized that low-dose intrapulmonary delivery of pirfenidone is effective in human transforming growth factorβ1-driven pulmonary fibrosis. To demonstrate our hypothesis, we compared the therapeutic efficacy of varying doses of pirfenidone administered by oral and intranasal routes in a human transforming growth factor-β1 transgenic mouse with established pulmonary fibrosis. We found similar amelioration of lung cell infiltration, inflammatory and fibrotic cytokines, lung fibrosis score, and hydroxyproline content in mice with human transforming growth factor-β1-mediated pulmonary fibrosis treated with low-dose intranasal pirfenidone and high-dose oral pirfenidone. This study showed that pirfenidone is a potent inhibitor of human transforming growth factor-β1-driven lung fibrosis and that intrapulmonary delivery of low-dose pirfenidone produces therapeutic responses equivalent to high-dose of oral pirfenidone.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774321 | PMC |
| http://dx.doi.org/10.3389/fphar.2020.593620 | DOI Listing |
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