AI Article Synopsis
- The Japan Environment and Children's Study (JECS) is a large study focused on how environmental factors impact children's health and development, with a new Sub-Cohort Study targeting a random subgroup from the main study for detailed assessments.
- Out of over 100,000 children in the main study, approximately 10,302 were selected, and 5,017 of them participated, with their backgrounds similar to those in the main group.
- This Sub-Cohort Study aims to provide valuable insights into the links between environmental exposure and children's health outcomes through comprehensive assessments and follow-ups.
Article Abstract
Background: The Japan Environment and Children's Study (JECS) is a nationwide birth cohort study investigating environmental effects on children's health and development. A Sub-Cohort Study has begun, conducting extended exposure and outcome measurements by targeting a subgroup randomly selected from the JECS Main Study. We report the Sub-Cohort Study methodology and participants' baseline profiles.
Methods: Of 100,148 children in the JECS Main Study, children born after April 1, 2013 who met eligibility criteria ([1] all questionnaire and medical record data from children and their mothers collected from the first trimester to 6 months of age, [2] biospecimens [except umbilical cord blood] from children and their mothers collected at first to second/third trimester and delivery) were randomly selected for each Regional Centre at regular intervals. Face-to-face assessment of neuropsychiatric development, body measurement, paediatrician's examination, blood/urine collection for clinical testing and chemical analysis, and home visits (ambient and indoor air measurement and dust collection) are conducted. Participants are followed up at 1.5 and 3 years old for home visits, and 2, 4, 6, and 8 years old for developmental/medical examination. The details of protocols after age 10 are under discussion.
Results: Of 10,302 selected children, 5,017 participated. The profiles of the participating mothers, fathers and children did not substantially differ between the Main Study and Sub-Cohort Study.
Conclusion: The JECS Sub-Cohort Study offers a platform for investigating associations between environmental exposure and outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979916 | PMC |
| http://dx.doi.org/10.2188/jea.JE20200448 | DOI Listing |
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