Recently, researchers have shown great interest in compounds such as triflate and enotriflate that are synthesized by Comins reagent. For the above-mentioned reason, we planned to review the works related to organic synthesis using Comins reagent. So this review includes a whole new investigation of the Comins reagent which is used for stereoselective conversion of α-keto ester, enolate to enol triflate of lactone and vinyl triflate to methyl ketone. Comins reagent plays an important role in regioselectivity such as transformations of ketone or dienolates into vinyl triflates and it has a major application in highly selective oxidation in an easy and environmentally friendly manner.
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