AI Article Synopsis
- Coronaviruses, particularly hCoV-HKU1, are under scrutiny due to their potential to cause mild to severe respiratory illness, as highlighted by the Covid-19 pandemic.
- The N-terminal domain of the nucleocapsid protein (N-NTD) plays a crucial role in regulating viral genome transcription and assembly by binding to specific RNA sequences.
- This study provides resonance assignments for the N-NTD of HKU1-CoV, offering insights into its structural and functional properties.
Article Abstract
Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. During viral replication, a discontinuous transcription of the genome takes place, producing the subgenomic messenger RNAs. The nucleocapsid protein (N) plays a pivotal role in the regulation of this process, acting as an RNA chaperone and participating in the nucleocapsid assembly. The isolated N-terminal domain of protein N (N-NTD) specifically binds to the transcriptional regulatory sequences and control the melting of the double-stranded RNA. Here, we report the resonance assignments of the N-NTD of HKU1-CoV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778850 | PMC |
| http://dx.doi.org/10.1007/s12104-020-09998-9 | DOI Listing |
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