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Classification of germline non-truncating variants: a new approach to interpretation.
J Med Genet
November 2024
Cancer Genetics Unit, Institut Bergonié, Bordeaux, Aquitaine, France.
Article Synopsis
- PTEN hamartoma tumour syndrome (PHTS) includes syndromes like Cowden syndrome, with missense variants making up 30% of PHTS cases, yet their classification is complex.
- A study from the Bergonie Institute identified 76 non-truncating variants in 166 patients, developing a new classification method using criteria like functional analysis, phenotypic features, and familial patterns.
- The new approach successfully reclassifies 25 variants, revealing the need to update current classification standards based on multiple factors, and it requires further validation in future research.
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups.
ALTEX
October 2024
Safety Assessment, Genentech Inc., South San Francisco, CA, USA.
The virtual control group (VCG) concept provides a potential opportunity to reduce animal use in drug development by replacing concurrent control groups (CCGs) in nonclinical toxicity studies. This work investigated the feasibility and reliability of using VCGs in place of CCGs. A historical control database (HCD), constructed from Genentech Inc.
View Article and Find Full Text PDFEvaluation of Artificial Intelligence-Based Gleason Grading Algorithms "in the Wild".
Mod Pathol
November 2024
Radboud University Medical Center, Computational Pathology Group, Nijmegen, The Netherlands.
The biopsy Gleason score is an important prognostic marker for prostate cancer patients. It is, however, subject to substantial variability among pathologists. Artificial intelligence (AI)-based algorithms employing deep learning have shown their ability to match pathologists' performance in assigning Gleason scores, with the potential to enhance pathologists' grading accuracy.
View Article and Find Full Text PDFA dataset of ground-dwelling nocturnal fauna for object detection and classification.
Data Brief
June 2024
UMR Agronomie, INRAE AgroParisTech, Université-Paris-Saclay, 22 place de l'agronomie, bâtiment F, F-91123 Palaiseau, France.
The exploration of ground-dwelling nocturnal fauna represents a significant challenge due to its broad implications across various sectors, including pesticide management, crop yield forecasting, and plant disease identification. This paper unveils an annotated dataset, BioAuxdataset, aimed at facilitating the recognition of such fauna through field images gathered across multiple years. Culled from a collection exceeding 100,000 raw field images over a span of four years, this meticulously curated dataset features seven prevalent species of nocturnal ground-dwelling fauna: carabid, mouse, opilion, slug, shrew, small-slug, and worm.
View Article and Find Full Text PDFOn the diversity of ideas in academic spaces.
Front Public Health
December 2023
Office of the Dean, School of Public Health, Boston University, Boston, MA, United States.
Universities and other academic spaces are social institutions that exist primarily for ideas-to generate, curate, and transmit ideas to students and to the world. Academic spaces cannot carry out that function without supporting a diversity of perspectives. At the same time, universities must reckon-as must all social institutions-with changing norms around how to engage with ideas that challenge, provoke, even anger members of the communities dedicated to their discussion.
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