Aim: To evaluate the utility of brain F-DOPA PET/CT in the differential diagnosis of brain lesions with inconclusive MRI.
Material And Methods: Twelve patients were studied, with a total of 16 lesions, without definitive diagnosis after brain MRI. A double acquisition PET/CT brain scan was acquired at 20 and 90 minutes. Visual and semiquantitative assessment was performed with SUV calculation of the lesions and calculation of the T/S ratio (tumor/contralateral striatum) and T/N ratio (tumor/contralateral healthy parenchyma) for each time.
Results: Based on the visual assessment scale and using T/S ratio ≥ 1 and T/N ratio ≥ 1.3 to determine malignancy, the values of sensitivity (S), specificity (E) and positive predictive value (PPV) were: visual assessment (S 100%, E 33.3%, VPP 71.4%), T/S ratio (S 90%, E 100%, VPP 100%) and T/N ratio (S 100%, E 16.6%, VPP 66.6%). No lesion showed an increase in SUV in late acquisition. F-DOPA PET/CT modified treatment in 75% of the patients.
Conclusion: F-DOPA PET/CT is a useful tool in the study of brain lesions with inconclusive MRI. Late imaging (dual-point) has no added value in the final diagnosis. F-DOPA has an impact on patient management modifying therapeutic behavior.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.remn.2020.10.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deciphering F-DOPA uptake in SDH-related head and neck paragangliomas: a radiomics approach.
J Endocrinol Invest
December 2024
Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.
Purpose: To investigate the influence of germline succinate dehydrogenase (SDHx) pathogenic variants on 6-[F]-fluoro-3,4-dihydroxyphenylalanine (F-DOPA) Positron Emission Tomography (PET) radiomic signature of head and neck paragangliomas (HNPGLs).
Methods: Forty-seven patients (20 SDH pathogenic variants carriers) harboring 55 HNPGLs were retrospectively included. HNPGLs were delineated using Nestle adaptive threshold.
A New Tool for Extracting Static and Dynamic Parameters from [F]F-DOPA PET/CT in Pediatric Gliomas.
J Clin Med
October 2024
Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16145 Genoa, Italy.
Article Synopsis
- PET imaging with [F]F-DOPA shows promise for assessing pediatric brain gliomas, but manual extraction of data is slow and inconsistent.
- A new semi-automated Python framework was developed to streamline the processing of PET images and improve efficiency and accuracy in calculating clinical scores.
- The study found that this new method significantly improved reproducibility in extracting important tumor metrics and reduced the variability associated with human input.
[18F]DOPA PET for lesion definition and contouring using different thresholds in patients with gliomas.
Q J Nucl Med Mol Imaging
September 2024
Nuclear Medicine Unit, Department of Medical Sciences, AOU Città della Salute e della Scienza, Turin, Italy -
Article Synopsis
- The study examines the effectiveness of ESTRO-EANO guidelines for RT-planning in glioblastomas using [F]DOPA-PET, comparing their target definition thresholds (1.6-1.8) with traditional biological-tumor-volume (BTV) thresholds derived from the striatum. !* -
- An analysis of 50 glioma patients found that the striatum SUV
max threshold often resulted in smaller and less accurate tumor volumes, with significant discrepancies noted in many cases. !* - - The research concludes that the ESTRO-EANO thresholds for defining tumor volume are compatible with [F]DOPA-PET scans, while using the striatal SUV
Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication.
Eur J Nucl Med Mol Imaging
December 2024
Vita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.
Article Synopsis
- Researchers did a review to update how good different types of PET scans are for finding and checking solid cancers (not brain cancers) using special medicines.
- They looked through many studies and found 64 helpful articles that show which types of PET scans work best for various cancers, like prostate and neuroendocrine tumors.
- The review found that some cancers, like esophageal cancer and certain types of lung cancer, don't have enough strong studies to help with diagnosis using PET scans.
Neck paragangliomas: a case report and literature review.
Acta Chir Belg
December 2024
Department of General and Endocrine Surgery, Onze-Lieve-Vrouw (OLV) Hospital Aalst, Aalst, Belgium.
Objective: Thyroid-originated paragangliomas are very uncommon, and there is a lack of established guidelines regarding their management.
Methods: A case study was presented, and a review of the literature was conducted.
Results: Diagnosing a paraganglioma requires multiple diagnostic methods, including a 24-h measurement of metanephrines or catecholamines, anatomical imaging using magnetic resonance or computed tomography (CT) scans, and functional imaging using metaiodobenzylguanidine or F-DOPA PET/CT scans.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!