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| http://dx.doi.org/10.1053/j.gastro.2020.12.050 | DOI Listing |
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Early Steroid Withdrawal Versus Steroid Maintenance in Adults Older than 65 Receiving Second Kidney Transplants.
Transplant Proc
December 2024
Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:
Background: The role of steroid maintenance (SM) therapy in older adults with kidney retransplants is uncertain due to the intricate balance between rejection and adverse event risks. We aimed to assess their long-term outcomes, comparing SM versus early steroid withdrawal (ESW).
Methods: Retrospective United Network for Organ Sharing registry cohort study.
Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children.
Cochrane Database Syst Rev
November 2024
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: About 80% of children with steroid-sensitive nephrotic syndrome (SSNS) have relapses. Of these children, half will relapse frequently, and are at risk of adverse effects from corticosteroids. While non-corticosteroid immunosuppressive medications prolong periods of remission, they have significant potential adverse effects.
View Article and Find Full Text PDFInterventions for BK virus infection in kidney transplant recipients.
Cochrane Database Syst Rev
October 2024
Department of Renal Medicine, The Canberra Hospital, Canberra, Australia.
Article Synopsis
- BK virus-associated nephropathy (BKVAN) is a complication in kidney transplantation due to BK virus infection, requiring careful screening and management primarily through reduced immunosuppression, as no effective antiviral therapy exists.
- This review evaluated the effectiveness and risks of various interventions for treating or preventing BKVAN among kidney transplant recipients, including examining randomized controlled trials and cohort studies.
- The review included 12 RCTs with a total of 2,669 participants, analyzing data through rigorous methods to assess the quality and effectiveness of these interventions.
Tacrolimus-Induced Recurrent Acute Coronary Syndrome Due to an Unknown Mechanism.
Cureus
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Internal Medicine, St. Luke's Hospital, Easton, USA.
Tacrolimus, a potent immunosuppressive agent widely used in solid organ transplantation, has been associated with numerous harmful side effects. We report an interesting case of a patient who is status post liver transplantation and who has been maintained on tacrolimus for the past 10 years. She presented in the hospital with a ST-segment elevation myocardial infarction (STEMI), with normal coronary angiography.
View Article and Find Full Text PDFCost-Effectiveness of Extracorporeal Photopheresis in Patients With Chronic Graft-vs-Host Disease.
J Health Econ Outcomes Res
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HTANALYSTS, Sydney, Australia.
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- The study evaluated the cost-effectiveness of extracorporeal photopheresis (ECP) compared to standard therapies for chronic graft-vs-host disease (cGVHD) in Australia, especially for patients who do not respond to corticosteroids.
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