AI Article Synopsis
- Researchers looked at how major depressive disorder (MDD) affects mitochondrial energy production and oxidative stress in women with mild to moderate depression.
- They found no significant differences in mitochondrial function or oxidative stress markers between 20 women with MDD and 24 non-depressed women.
- The study suggests that changes in mitochondrial energy and oxidative stress may be more related to severe or chronic depression, rather than mild cases.
Article Abstract
Major depressive disorder (MDD) has been associated with lower mitochondrial energy production and higher oxidative stress. We investigated whether these alterations manifest in patients with current mild to moderate MDD severity. We observed no differences in mitochondrial respiration and density (i.e., citrate-synthase activity) in peripheral blood mononuclear cells and oxidative stress markers (i.e., 8-hydroxy-2'-deoxyguanosine, 8-isoprostane) in blood serum of 20 female MDD patients compared to 24 non-depressed women. Alterations in mitochondrial energy production and oxidative stress did not linearly depend on the current severity of MDD. However, biological alterations might rather manifest with higher MDD severity/chronicity and at higher age.
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| http://dx.doi.org/10.1016/j.mito.2020.12.009 | DOI Listing |
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