Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. -Lapachone (-Lap) is a natural compound obtained from Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of -Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, -Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, -Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with -Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the -Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749764 | PMC |
| http://dx.doi.org/10.1155/2020/8820651 | DOI Listing |
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