AI Article Synopsis
- The study explores the potential of creating mature thyroid follicular cells from pluripotent stem cells to treat hypothyroidism, addressing the challenges of differentiation.
- Researchers discovered that thyroids in a specific mutant mouse model (Ex1/Ex3) showed severe underdevelopment, which helped inform their experiments.
- By using embryonic stem cells in blastocyst complementation, they successfully produced normal and functional thyroid tissues, indicating a promising method for thyroid regeneration.
Article Abstract
The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but differentiation remains difficult. We earlier reported the generation of lung organs blastocyst complementation in fibroblast growth factor 10 (), compound, heterozygous mutant ( Ex1/Ex3) mice. Fgf10 also plays an essential role in thyroid development and branching morphogenesis, but any role thereof in thyroid organogenesis remains unclear. Here, we report that the thyroids of Ex1/Ex3 mice exhibit severe hypoplasia, and we generate thyroid tissues from mouse embryonic stem cells (ESCs) in Ex1/Ex3 mice blastocyst complementation. The tissues were morphologically normal and physiologically functional. The thyroid follicular cells of Ex1/Ex3 chimeric mice were derived largely from GFP-positive mouse ESCs although the recipient cells were mixed. Thyroid generation blastocyst complementation will aid functional thyroid regeneration.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767966 | PMC |
| http://dx.doi.org/10.3389/fendo.2020.609697 | DOI Listing |
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