AI Article Synopsis
- Lymphoblastic lymphoma (LBL) is a common pediatric non-Hodgkin lymphoma with treatment protocols showing varied results and associated toxicities.
- A study of 63 LBL patients from 1991 to 2018 revealed a 5-year event-free survival rate of 68.8% and no significant difference in outcomes between the NY and ALL treatment protocols.
- The study emphasizes the need for ongoing evaluation of chemotherapy regimens to enhance treatment effectiveness while considering long-term side effects for young patients.
Article Abstract
Background: Lymphoblastic lymphoma (LBL) is the second most common subtype of pediatric non-Hodgkin lymphoma. Modified treatments derived from the LSA2-L2 regimen resulted in encouraging survival, but toxicities and long-term sequelae have been problematic. At present, the acute lymphoblastic leukemia (ALL)-type protocol has demonstrated efficacy in LBL. We analyzed the outcomes of children and adolescents with LBL treated with various regimens.
Methods: From 1991‒2018, this study enrolled 63 patients diagnosed with LBL at Asan Medical Center. Medical records were retrospectively analyzed.
Results: Among 63 patients, most patients (38.1%) presented with stage IV at diagnosis, and two had central nervous system (CNS) involvement. At a median follow-up of 160 months, the 5-year event free survival (EFS), overall survival (OS), and relapse free survival (RFS) were 68.8%, 79.3%, and 71.3%, respectively. Among 61 patients who received chemotherapy, 27 patients (44.3%) received the NY protocol, and 14 (23.0%) received the ALL-type protocol. There was no significant difference in 5-yr OS (85.2%/78.6%), EFS (73.5%/78.6%), and RFS (73.5%/78.6%) between the NY and ALL protocol groups, regardless of immunophenotype. Thirteen patients (21.3%) received prophylactic cranial radiotherapy with no difference in the incidence of CNS relapse based on irradiation.
Conclusion: This study showed no difference in outcome between the NY and ALL-type protocols, regardless of stage or immunophenotype. In addition to improving the effectiveness of treatment, it is necessary to continuously appraise the appropriate chemotherapy regimen, considering toxicities and long-term prognosis, for pediatric LBL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784128 | PMC |
| http://dx.doi.org/10.5045/br.2020.2020220 | DOI Listing |
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