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Skewed thermodynamic geometry and optimal free energy estimation. | LitMetric

Skewed thermodynamic geometry and optimal free energy estimation.

J Chem Phys

Department of Physics, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Published: December 2020

AI Article Synopsis

Article Abstract

Free energy differences are a central quantity of interest in physics, chemistry, and biology. We develop design principles that improve the precision and accuracy of free energy estimators, which have potential applications to screening for targeted drug discovery. Specifically, by exploiting the connection between the work statistics of time-reversed protocol pairs, we develop near-equilibrium approximations for moments of the excess work and analyze the dominant contributions to the precision and accuracy of standard nonequilibrium free-energy estimators. Within linear response, minimum-dissipation protocols follow the geodesics of the Riemannian metric induced by the Stokes friction tensor. We find that the next-order contribution arises from the rank-3 supra-Stokes tensor that skews the geometric structure such that minimum-dissipation protocols follow the geodesics of a generalized cubic Finsler metric. Thus, near equilibrium, the supra-Stokes tensor determines the leading-order contribution to the bias of bidirectional free-energy estimators.

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Source
http://dx.doi.org/10.1063/5.0033405DOI Listing

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