AI Article Synopsis
- Acute pressure chamber hypoxia in rats negatively impacts the surfactant system and respiratory structure, leading to reduced surface activity and altered surfactant fluorescence.
- On the first day, atelectatic foci (collapsed lung areas) are more prevalent than emphysema, but lung structure returns to normal with time.
- During de-adaptation, surfactant activity and fluorescence levels exceed normal, while the presence of phagocytized surfactant in alveolar macrophages increases, showing a contrasting response to extracellular surfactant changes.
Article Abstract
The effect of acute pressure chamber hypoxia on the surfactant system and respiratory segment structure of the lungs were studied in rats by physical, fluorescent microscopic and morphometric methods. Acute hypoxia decreases surface activity, induces changes in cellular and extracellular surfactant fluorescence and causes the development of diffuse vesicular emphysema. On the first day of adaptation atelectatic foci dominate over emphysema, and the pulmonary structure normalizes afterwards. During de-adaptation, surface activity and cellular surfactant fluorescence are higher than the control levels. Surface activity and extracellular surfactant fluorescence recover steadily by the fifth day of adaptation. The amount of phagocytized surfactant in alveolar macrophages is increased, with the changes being opposite to those characteristic of extracellular surfactant.
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