Mathematical modeling for cancerous disease has attracted increasing attention from the researchers around the world. Being an effective tool, it helps to describe the processes that happen to the tumour as the diverse treatment scenarios. In this paper, a density-dependent reaction-diffusion equation is applied to the most aggressive type of brain cancer, Glioblastoma multiforme. The model contains the terms responsible for the growth, migration and proliferation of the malignant tumour. The traveling wave solution used is justified by stability analysis. Numerical simulation of the model is provided and the results are compared with the experimental data obtained from the reference papers.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3934/mbe.2020371 | DOI Listing |
Magn Reson Med
January 2025
MRI Research Centre, Physics, University of New Brunswick, Fredericton, New Brunswick, Canada.
Purpose: Magnetic resonance elastography (MRE) provides detailed maps of tissue stiffness, helping to diagnose various health conditions, but requires the use of expensive clinical MRI scanners. Our approach utilizes compact, cost-effective portable MR sensors that offer bulk characterization of material properties in a region of interest close to the surface (within 1-2 cm). This accessible instrument could enable routine monitoring and prevention of diseases not readily evaluated with conventional tools.
View Article and Find Full Text PDFLancet Neurol
February 2025
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada; Department of Cognitive Neurology, St Joseph's Health Care London, London, ON, Canada. Electronic address:
Background: No treatments exist for apathy in people with frontotemporal dementia. Previously, in a randomised double-blind, placebo-controlled, dose-finding study, intranasal oxytocin administration in people with frontotemporal dementia improved apathy ratings on the Neuropsychiatric Inventory over 1 week and, in a randomised, double-blind, placebo-controlled, crossover study, a single dose of 72 IU oxytocin increased blood-oxygen-level-dependent signal in limbic brain regions. We aimed to determine whether longer treatment with oxytocin improves apathy in people with frontotemporal dementia.
View Article and Find Full Text PDFMicromachines (Basel)
January 2025
Department of Astronautical, Electrical and Energy Engineering, University of Rome "La Sapienza", Via Eudossiana 18, 00184 Rome, Italy.
The propagation of interface acoustic waves (IAWs) in 128° YX-LiNbO/SU-8/overcoat structures was theoretically studied and experimentally investigated for different types of overcoat materials and thicknesses of the SU-8 adhesive layer. Three-dimensional finite element method analysis was performed using Comsol Multiphysics software to design an optimized multilayer configuration able to achieve an efficient guiding effect of the IAW at the LiNbO/overcoat interface. Numerical analysis results showed the following: (i) an overcoat faster than the piezoelectric half-space ensures that the wave propagation is confined mainly close to the surface of the LiNbO, although with minimal scattering in the overcoat; (ii) the presence of the SU-8, in addition to performing the essential function of an adhesive layer, can also promote the trapping of the acoustic energy toward the surface of the piezoelectric substrate; and (iii) the electromechanical coupling efficiency of the IAW is very close to that of the surface acoustic wave (SAW) along the bare LiNbO half-space.
View Article and Find Full Text PDFMicromachines (Basel)
December 2024
School of Intelligent Equipment, Shandong University of Science and Technology, Tai'an 271019, China.
The flexible rotor, as a crucial component of the traveling wave rotary ultrasonic motor, effectively reduces radial friction. However, issues such as uneven contact between the stator and rotor, as well as rotor-deformation-induced stress, still persist. This paper presents an optimization method that combines the Kriging response surface model with a multi-objective genetic algorithm (MOGA).
View Article and Find Full Text PDFSci Rep
January 2025
Healthcare Technology Innovation Centre, Indian Institute of Technology Madras, Chennai, India.
The local pulse wave velocity (PWV) from large elastic arteries and its pressure-dependent changes within a cardiac cycle are potential biomarkers for cardiovascular risk stratification. However, pulse wave reflections can impair the accuracy of local PWV measurements. We propose a method to measure pressure-dependent variations in local PWV while minimizing the influence of pulse wave reflections.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!