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Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports.
Front Med (Lausanne)
December 2024
Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', AORN Ospedali dei Colli, Naples, Italy.
Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This article presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications.
View Article and Find Full Text PDFWomen and the Heart: Webcast April 16 2024.
Methodist Debakey Cardiovasc J
December 2024
University of Florida College of Medicine, Jacksonville, Florida, US.
This 62-minute webcast features a conversation about "Women and the Heart: Gender-Related Differences in Cardiovascular Care"-the focus of Issue 20.2. Led by the issue's editor, the discussion engages the authors on emerging themes and lessons learned while researching and writing the articles.
View Article and Find Full Text PDFRisk Factors and Outcomes of Acute Pulmonary Embolism in African Patients: A Systematic Review.
Cureus
November 2024
Cardiothoracic Surgery Unit, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, NGA.
Pulmonary embolism is a common cause of morbidity and mortality. Numerous risk factors have been identified that predispose patients to this disease. This study aims to identify these risk factors and the possible outcomes (recovery or mortality) after receiving treatment from any hospital.
View Article and Find Full Text PDFEisenmenger syndrome during pregnancy: A true anesthetic challenge.
Med J Armed Forces India
December 2024
Professor & Senior Advisor, (Anaesthesia & Critical Care), Command Hospital (Eastern Command), Kolkata, West Bengal, India.
Eisenmenger syndrome (ES) is a rare congenital heart disease (CHD) that occurs in persons with large intracardiac anatomical defects which may go undetected for many years, consequently results in reduced life expectancies and high mortality in the third and fourth decade of life. Pregnancy in patients with CHD and pulmonary arterial hypertension (PAH) is presaged with challenges, and perioperative management of such cases remains a topic of debate. Our case had both, atypical presentation, not diagnosed until her third trimester of third pregnancy and a quick progression to a severe stage with PAH and CorPulmonale.
View Article and Find Full Text PDFRisk of venous thromboembolic complications in pregnant trauma patients: A matched cohort study.
World J Surg
December 2024
Division of Acute Care Surgery, University of Southern California, Los Angeles, California, USA.
Background: Trauma and pregnancy are both risk factors for venous thromboembolism (VTE). We hypothesized that pregnant blunt trauma patients would have a higher incidence of VTE complications compared with matched nonpregnant females.
Methods: We conducted a retrospective cohort study using National Trauma Data Bank data from 2017 to 2022.
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