AI Article Synopsis
- * The chemical structures of these isolated compounds were analyzed using detailed spectroscopic methods.
- * Biological tests revealed that while none of the compounds activated PPAR-γ, one compound significantly reduced IL-1 production in macrophages and others showed cytotoxic effects against various cancer cell lines.
Article Abstract
Chemical investigation of the marine soft coral resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (), three new cembranoids, sarcotenusenes A‒C (‒), and ten previously reported metabolites -. The chemical structures of all isolated metabolites were determined by detailed spectroscopic analyses. In biological assays, anti-inflammatory, cytotoxic, and peroxisome proliferator-activated receptor γ (PPAR-γ) transcription factor assays of all compounds were performed. None of the isolated compounds were found to exhibit activity in the PPAR-γ transcription factor assay. The anti-inflammatory assays showed that (+)-7,8-dihydroxydeepoxysarcophine () inhibited the production of IL-1 to 56 ± 1% at a concentration of 30 M in lipopolysaccharide (LPS)-stimulated J774A.1 macrophage cells. In addition, and were found to exhibit cytotoxicity towards a panel of cancer cell lines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823492 | PMC |
| http://dx.doi.org/10.3390/md19010008 | DOI Listing |
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