Adiponectin (APN) is suggested to be a potential biomarker for predicting diabetic retinopathy (DR) risk, but the association between APN and DR has been inconsistent in observational studies. We used a Mendelian randomization (MR) analysis to evaluate if circulating APN levels result in DR. We applied three different genetic risk scores (GRS): GRS combined all 47 single nucleotide polymorphisms (SNPs), which from a genome-wide association study (GWAS) database-catalog reach significance level; GRS comprised 16 GRS-SNPs with a rigorous threshold ( < 5.0 × 10 for GWAS), and GRS combined 5 SNPs significantly associated with APN level. The MR-inverse-variance weighted method analysis showed that for each 1-SD increase in genetically induced increase in plasma APN, the OR of having DR was β = 0.20 (95% CI: -0.46-0.85, = 0.553) for GRS, 0.61 (95% CI: 0.10-1.13, = 0.020) for GRS, and 0.57 (95% CI: -0.06 to 1.20, = 0.078) for GRS. Sensitivity analysis, including MR-egger regression and the weighted-median approach, did not provide evidence of the pleiotropic effect of IVs. Limited evidence for the causal role of APN in DR risk among Taiwanese diabetic patients was shown based on MR analysis in the present study.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823606PMC
http://dx.doi.org/10.3390/genes12010017DOI Listing

Publication Analysis

Top Keywords

diabetic retinopathy
8
mendelian randomization
8
grs combined
8
grs
7
apn
6
causal relationship
4
relationship adiponectin
4
adiponectin diabetic
4
retinopathy mendelian
4
randomization study
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!