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Cracking the code of adaptive immunity: The role of computational tools.
Cell Syst
December 2024
Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:
In recent years, the advances in high-throughput and deep sequencing have generated a diverse amount of adaptive immune repertoire data. This surge in data has seen a proportional increase in computational methods aimed to characterize T cell receptor (TCR) repertoires. In this perspective, we will provide a brief commentary on the various domains of TCR repertoire analysis, their respective computational methods, and the ongoing challenges.
View Article and Find Full Text PDFCracking the code of aldosterone synthase deficiency: bridging genetics and biochemistry: a case report.
Lab Med
December 2024
Department of Pediatrics, AIIMS Patna, Patna, Bihar, India.
Objective: Aldosterone synthase deficiency (ASD) is a rare autosomal recessive inherited disease with an overall clinical phenotype of failure to thrive, vomiting, severe dehydration, hyperkalemia, and hyponatremia. Mutations in the CYP11B2 gene encoding AS are responsible for the occurrence of ASD. Defects in CYP11B2 gene have only been reported in a limited number of cases worldwide.
View Article and Find Full Text PDFRoad properties of cement-phosphogypsum-red clay under dry and wet cycles.
PLoS One
December 2024
School of Civil Engineering, Guizhou University, Guiyang, Guizhou Province, China.
In this paper, the road performance and mechanism of cement-phosphogypsum-red clay (CPRC) under dry and wet cycling were systematically investigated using 5% cement as curing agent, the mass ratio of phosphogypsum: red clay = 1:1, and 5% SCA-2 as water stabilizer. The road performance of dry and wet cycle mix was verified with the National Highway G210 Duyun Yangan to Yingshan Highway Reconstruction and Expansion Project as a test road to provide a scientific basis for the application of cement-phosphogypsum-red clay on roads. The results show that the cement-phosphogypsum-red clay unconfined compressive strength decreases with the increase of the number of wet and dry cycles, with a larger decay in the first three times and leveling off thereafter.
View Article and Find Full Text PDFAnyone recounting the history of cognitive psychology will have to make early mention of the study of orthographic processing (starting in 1886 with the seminal work of Cattell, a doctoral student of Wilhelm Wundt); and anyone recounting the study of orthographic processing will have to make mention of Jonathan Grainger. An honorary member and former president of the European Society for Cognitive Psychology, Jonathan has dedicated nearly four decades of research to the mechanisms driving the recognition of letters, words and sentences during reading. In honour of Jonathan's career-which formally has come to a close in 2023-in this Special Issue several contemporaries and close collaborators highlight important advances that have been made in the past 40 years, and provide flavours of where the field stands today.
View Article and Find Full Text PDFBone marrow mesenchymal stem cells (BM-MSCs) modulate MMP9 expression and promote articular cartilage regeneration in knee joint of a model of arthritis induced in adult rat: histological and immunohistochemical study.
J Mol Histol
December 2024
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Arthritis is characterized by the progressive degeneration of articular cartilage, and the avascular nature of cartilage limits its capacity for self-repair. Stem cells are considered a promising treatment option due to their multipotent differentiation potential. The aim of this work was to investigate the structural changes in the hyaline articular cartilage of the knee joint in a model of arthritis induced by complete Freund's adjuvant, and to assess intra-articular injection of bone marrow mesenchymal stem cells (BM-MSCs) through both histological and immunohistochemical study.
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