Three new human leukocyte antigen (HLA)-C alleles, C*04:01:124, C*12:02:38, and C*12:03:64, alleles detected in Russian individuals.
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http://dx.doi.org/10.1111/tan.14178 | DOI Listing |
Biomedica
December 2024
Servicio de Reumatología e Inmunología, Hospital Militar Central, Bogotá, D. C., Colombia; Grupo de Inmunología Clínica Aplicada, Hospital Militar Central, Universidad Militar Nueva Granada, Bogotá, D. C., Colombia; Grupo de Inmunología Celular y Molecular - InmuBo, Universidad El Bosque, Bogotá, D. C., Colombia.
Unlabelled: Introducción. La artritis psoriásica es una enfermedad compleja y los antígenos leucocitarios humanos (Human Leukocyte Antigen, HLA) son un factor clave en el desarrollo de la enfermedad. En Latinoamérica, hay pocos datos sobre dichos antígenos en pacientes con artritis psoriásica.
View Article and Find Full Text PDFFront Immunol
January 2025
Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Human Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4) insufficiency caused by heterozygous germline mutations in is a complex immune dysregulation and immunodeficiency syndrome presenting with reduced penetrance and variable disease expressivity, suggesting the presence of disease modifiers that trigger the disease onset and severity. Various genetic and non-genetic potential triggers have been analyzed in CTLA-4 insufficiency cohorts, however, none of them have revealed a clear association to the disease. Multiple HLA haplotypes have been positively or negatively associated with various autoimmune diseases and inborn errors of immunity (IEI) due to the relevance of MHC in the strength of the T cell responses.
View Article and Find Full Text PDFHLA
January 2025
Department of Hematology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China.
The HLA-C*03:681 allele differs from HLA-C*03:02:02:01 by a single non-synonymous nucleotide change in exon 3.
View Article and Find Full Text PDFFour novel null-alleles are described from bone marrow donors of Russian Registry.
View Article and Find Full Text PDFHLA
January 2025
Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The HLA-C*01:250 allele differs from HLA-C*01:02:01:01 by a single non-synonymous nucleotide change in exon 7.
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