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| http://dx.doi.org/10.1093/cid/ciaa1899 | DOI Listing |
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Developing a cost-effective and efficient safety case management solution for data coordinating center projects.
Contemp Clin Trials
January 2025
RTI International Center for Clinical Research, 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA. Electronic address:
A centralized safety function can support multiple clinical trials and provide efficient, standardized processes for the management of serious adverse events. From 2017 to 2022, the centralized safety desk used pharmacovigilance software compliant with FDA regulations, including 21 CFR Part 11. This software assisted with processing safety cases for regulated clinical trials, including allowing capture of event data, and provided process flow management, documentation storage, and transmission of safety reports to FDA.
View Article and Find Full Text PDFCan We Ever Develop an Ideal RNA Force Field? Lessons Learned from Simulations of the UUCG RNA Tetraloop and Other Systems.
J Chem Theory Comput
January 2025
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno, Czech Republic.
Molecular dynamics (MD) simulations are an important and well-established tool for investigating RNA structural dynamics, but their accuracy relies heavily on the quality of the employed force field (). In this work, we present a comprehensive evaluation of widely used pair-additive and polarizable RNA s using the challenging UUCG tetraloop (TL) benchmark system. Extensive standard MD simulations, initiated from the NMR structure of the 14-mer UUCG TL, revealed that most s did not maintain the native state, instead favoring alternative loop conformations.
View Article and Find Full Text PDFDeveloping a New Paradigm for Healthcare Delivery: Lessons Learned from Same-Day Access.
J Healthc Manag
January 2025
Department of Radiation Oncology, University of California, Irvine, Chao Family Comprehensive Cancer Center, Orange, California.
Goal: Excessively lengthy wait times for appointments with clinicians are a major source of frustration for patients, and difficulties with access represent a public health problem facing populations across all societies. As delays in care have been associated with inferior outcomes, same-day appointments have been proposed as a patient-centric means of improving healthcare delivery. However, this paradigm represents a radical shift from conventional scheduling tactics, and skepticism has long existed regarding its feasibility and real-world applicability to clinical practice.
View Article and Find Full Text PDFGender analysis is not only about gender: reshaping the potato breeding priorities to increase varietal adoption in Kenya.
Front Sociol
December 2024
Genetics, Genomics and Crop Improvement Division, International Potato Center (CIP), Nairobi, Kenya.
Public breeding programs are pushing to implement demand-led breeding to increase variety adoption, while tackling multiple challenges for increased production under climate change. This has included the improvement of variety target product profiles involving multiple stakeholders. A special case involves the unexpected and rapid spread of the Shangi potato variety in Kenya.
View Article and Find Full Text PDFDelivering the news of an intraoperative death; literature-based guidance from the American Association for Thoracic Surgery Wellness Committee.
J Thorac Cardiovasc Surg
December 2024
Norton Thoracic Institute, Dignity Health, Phoenix, Ariz.
Objectives: Fortunately, operating room deaths and unexpected deaths are infrequent occurrences. However, when they occur, the surgeon is called upon to deliver this news to family and loved ones. There is a paucity of literature on this topic and little guidance preparing cardiothoracic surgeons for this important but difficult situation.
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