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Evidence for the Role of the Mitochondrial ABC Transporter MDL1 in the Uptake of Clozapine and Related Molecules into the Yeast .
Pharmaceuticals (Basel)
July 2024
GeneMill Biofoundry, Liverpool Shared Research Facilities, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.
Article Synopsis
- Clozapine can be toxic when it builds up in white blood cells, so understanding the transporters involved is important.
- Researchers developed a CRISPR-Cas9 yeast library to identify which transporters were responsible for clozapine resistance, discovering that the absence of the MDL1 transporter led to increased resistance.
- The study indicates that the mitochondrial MDL1 transporter is crucial for clozapine accumulation, with its human equivalent being ABCB10.
MetaLAB-HOI: Template standardization of health outcomes enable massive and accurate detection of adverse drug reactions from electronic health records.
Pharmacoepidemiol Drug Saf
January 2024
Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Purpose: This study aimed to advance the MetaLAB algorithm and verify its performance with multicenter data to effectively detect major adverse drug reactions (ADRs), including drug-induced liver injury.
Methods: Based on MetaLAB, we created an optimal scenario for detecting ADRs by considering demographic and clinical records. MetaLAB-HOI was developed to identify ADR signals using common model-based multicenter electronic health record (EHR) data from the clinical health outcomes of interest (HOI) template and design for drug-exposed and nonexposed groups.
Impact of somatostatin interneurons on interactions between barrels in plasticity induced by whisker deprivation.
Sci Rep
October 2022
Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteur 3, 02-093, Warsaw, Poland.
The activity of inhibitory interneurons has a profound role in shaping cortical plasticity. Somatostatin-expressing interneurons (SOM-INs) are involved in several aspects of experience-dependent cortical rewiring. We addressed the question of the barrel cortex SOM-IN engagement in plasticity formation induced by sensory deprivation in adult mice (2-3 months old).
View Article and Find Full Text PDFProlactin levels influenced by antipsychotic drugs in schizophrenia: A systematic review and network meta-analysis.
Schizophr Res
November 2021
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Prolactin increase is a common side effect in antipsychotic treatment of schizophrenia, which crucially impacts drug choice and treatment compliance. As previous reviews by our group on this topic have included only few Chinese studies, we aimed to compare and rank antipsychotics based on broader evidence. This systematic review pooled data of 92 included studies from previous systematic review by Huhn et al.
View Article and Find Full Text PDFMassive Clozapine Overdose: What to Expect?
Psychiatr Danub
January 2021
Division of Clinical Pharmacology, Department of Medicine, University Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia,
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