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Copper and Zinc Copromoted Bromo(chloro)trifluoromethylation of Alkenes and Alkynes with Trifluoromethanesulfonic Anhydride. | LitMetric
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Copper and Zinc Copromoted Bromo(chloro)trifluoromethylation of Alkenes and Alkynes with Trifluoromethanesulfonic Anhydride.

Yao Ouyang Chao-Lai Tong Xiu-Hua Xu Feng-Ling Qing

Org Lett

Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Published: January 2021

The first copper and zinc copromoted trifluoromethylation using trifluoromethanesulfonic anhydride (TfO) as a trifluoromethylating reagent has been developed. The reaction of alkenes or alkynes with TfO in the presence of CuX (X = Br, Cl), Zn powder, and 2,2'-bipyridine affords bromo(chloro)trifluoromethylated products in good yields. CuX plays a dual role as the catalyst and halide source, whereas 2,2'-bipyridine acts as both the activation reagent and ligand.

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 Source
http://dx.doi.org/10.1021/acs.orglett.0c03855DOI Listing

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