AI Article Synopsis
- Accelerated long-term forgetting (ALF) is a rapid loss of information that can occur within days or weeks, even when information is normally learned.
- This study focused on comparing ALF in individuals who carry the APOE ɛ4 gene, which is linked to Alzheimer's disease, to those who do not carry the gene, while also checking for connections to Alzheimer's biomarkers in cerebrospinal fluid (CSF).
- Results showed that APOE ɛ4 carriers experienced significant ALF over three months, and this was correlated with abnormal levels of Aβ/ptau ratios in CSF, suggesting ALF may indicate early signs of cognitive decline related to Alzheimer's disease.
Article Abstract
Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. We examined ALF in APOE ɛ4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE ɛ4 carriers (F(1,19) = 5.60; P < 0.05; Cohen's d = 1.08), and this performance was associated with abnormal levels of the CSF Aβ /ptau ratio (r = -.614; P < 0.01). Our findings indicate that ALF is detectable in at-risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886043 | PMC |
| http://dx.doi.org/10.1002/acn3.51245 | DOI Listing |
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