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| http://dx.doi.org/10.1111/ijcp.13925 | DOI Listing |
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Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment.
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Department of Internal Medicine, Evangelismos General Hospital, 45-47 Ipsilantou Str., 10676 Athens, Greece.
Obesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic alterations, insulin resistance, and lipid accumulation. These processes can culminate in histopathological changes collectively referred to as obesity-related glomerulopathy (ORG).
View Article and Find Full Text PDFHigh fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice.
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January 2025
Québec Heart and Lung Institute Research Center, Université Laval - 2725, Ch. Sainte-Foy, Québec, QC, Canada, G1V 4G5; Department of Medicine, Faculty of Medicine, Université Laval - 1050 Av. de la Médecine, Québec, QC, Canada, G1V 0A6; Institute of Nutrition and Functional Foods, Université Laval - 2440 Bd. Hochelaga, Québec, QC, Canada, G1V 0A6. Electronic address:
Background: Increased fructose consumption contributes to type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanisms are ill-defined. Gut nutrient sensing involves enterohormones like Glucagon-like peptide (Glp)2, which regulates the absorptive capacity of luminal nutrients. While glucose is the primary dietary energy source absorbed in the gut, it is unknown whether excess fructose alters gut glucose sensing to impair blood glucose regulation and liver homeostasis.
View Article and Find Full Text PDFUnveiling the role of OsSAP17: Enhancing plant resistance to drought and salt.
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College of Ecology and Environment, Chengdu University of Technology, Sichuan, 610059, China; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Monitoring for Heavy Metal Pollutants, Ministry of Ecology and Environment, Hunan, 410019, China. Electronic address:
With the intensification of climate change coupled with the inadequate agricultural management in certain regions, plants face numerous challenges due to various abiotic stresses. Stress associated proteins (SAPs) are essential functional genes in plants for coping with stress. This research provides a functional analysis of OsSAP17, a protein belonging to the SAP family in rice.
View Article and Find Full Text PDFDynamics and regulatory roles of RNA mA methylation in unbalanced genomes.
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Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China.
-methyladenosine (mA) in eukaryotic RNA is an epigenetic modification that is critical for RNA metabolism, gene expression regulation, and the development of organisms. Aberrant expression of mA components appears in a variety of human diseases. RNA mA modification in has proven to be involved in sex determination regulated by and may affect X chromosome expression through the MSL complex.
View Article and Find Full Text PDFUnravelling the case of suspected ectopic ureter in a young adult patient.
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March 2025
Department of Radiology, Hasan Sadikin Academic Medical Center-Faculty of Medicine, University of Padjadjaran, Jatinangor, Indonesia.
An ectopic ureter (EU) opens outside the bladder's trigone, a rare condition with an incidence of 0.05%-0.025%.
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