AI Article Synopsis
- Various demographic and clinical characteristics, such as age and chronic conditions, significantly affect COVID-19 outcomes, with older adults showing notably higher case fatality rates.
- A review of 28 studies found a wide range in sample sizes and ages, with common chronic conditions like hypertension and diabetes linked to increased risks of severe outcomes.
- A shift from analyzing individual chronic conditions to understanding the combined impact of multiple health issues and age on COVID-19 results is necessary for a comprehensive assessment.
Article Abstract
Background: Various patient demographic and clinical characteristics have been associated with poor outcomes for individuals with coronavirus disease 2019 (COVID-19). To describe the importance of age and chronic conditions in predicting COVID-19-related outcomes.
Methods: Search strategies were conducted in PubMed/MEDLINE. Daily alerts were created.
Results: A total of 28 studies met our inclusion criteria. Studies varied broadly in sample size (n = 21 to more than 17,000,000). Participants' mean age ranged from 48 years to 80 years, and the proportion of male participants ranged from 44% to 82%. The most prevalent underlying conditions in patients with COVID-19 were hypertension (range: 15%-69%), diabetes (8%-40%), cardiovascular disease (CVD) (4%-61%), chronic pulmonary disease (1%-33%), and chronic kidney disease (range 1%-48%). These conditions were each associated with an increased in-hospital case fatality rate (CFR) ranging from 1% to 56%. Overall, older adults have a substantially higher case fatality rate (CFR) as compared to younger individuals affected by COVID-19 (42% for those <65 vs 65% > 65 years). Only one study examined the association of chronic conditions and the risk of dying across different age groups; their findings suggested similar trends of increased risk in those < 65 years and those > 65 years as compared to those without these conditions.
Conclusions: There has been a traditional, single-condition approach to consideration of how chronic conditions and advancing age relate to COVID-19 outcomes. A more complete picture of the impact of burden of multimorbidity and advancing patient age is needed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799222 | PMC |
| http://dx.doi.org/10.1093/gerona/glaa320 | DOI Listing |
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