Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.
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http://dx.doi.org/10.1039/d0bm01677b | DOI Listing |
Nanoscale Adv
January 2025
Department of Materials Science, University of Milano-Bicocca Via Cozzi 55 Milano I-20125 Italy
Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent a promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators for radiation oncology, showing potential to improve therapeutic results compared to traditional protocols. In this work, we studied SiO/ZnO nanoparticles functionalized with porphyrin as a photosensitizer, capable of producing cancer cytotoxic reactive oxygen species for possible use in radio-oncological therapeutics.
View Article and Find Full Text PDFNanoscale Adv
January 2025
Department of Mechanical Engineering, Yeungnam University Gyeongsan-si 38451 Gyeongbuk Republic of Korea
In this study, dye/polymer matrix-stabilized β-FeOOH nanomaterials were fabricated for therapeutic applications. Rh-B/F127@β-FeOOH nanomaterials were synthesized using two different methods: co-precipitation (CoP) and hydrothermal (HT) methods. The as-synthesized nanoparticles were characterized using various spectroscopic techniques, including FT-IR, UV-Vis, PL, XRD, HR-TEM, and XPS analysis.
View Article and Find Full Text PDFNanoscale
January 2025
Nanomaterials for BioImaging Group (nanoBIG), Departamento de Física de Materiales, Universidad Autónoma de Madrid (UAM), Madrid 28049, Spain.
All-optical theranostic systems are sought after in nanomedicine, since they combine in a single platform therapeutic and diagnostic capabilities. Commonly in these systems the therapeutic and diagnostic/imaging functions are accomplished with plasmonic photothermal agents and luminescent nanoparticles (NPs), respectively. For maximized performance and minimized side effects, these two modalities should be independently activated, , in a decoupled way, using distinct near infrared (NIR) wavelengths: a radiation window wherein photon-tissue interaction is reduced.
View Article and Find Full Text PDFAdv Mater
January 2025
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, 410082, China.
During cancer peritoneal metastasis (PM), conventional antigen-presenting cells (dendritic cells, macrophages) promote tumorigenesis and immunosuppression in peritoneal cavity. While intraperitoneal immunotherapy (IPIT) has been used in clinical investigations to relieve PM, the limited knowledge of peritoneal immunocytes has hindered the development of therapeutic IPIT. Here, a dendritic cell-independent, next-generation IPIT is described that activates peritoneal cavity B (PerC B) cell subsets for intraperitoneal anti-tumor immunity via exogenous antigen presentation.
View Article and Find Full Text PDFAnal Chem
January 2025
Shandong Provincial Key Laboratory of Tumor Imaging Equipment Development and Integrated Diagnosis and Treatment Technology, Linyi University, Linyi 276000, China.
Drug-induced liver injury (DILI) has emerged as an urgent clinical challenge. It is characterized by mitochondrial dysfunction in liver cells, which leads to abnormal changes in HO levels within the mitochondria. Super-resolution imaging allows for the observation of the fine structure of mitochondria at the nanometer scale, potentially enabling the detection of mitochondrial HO levels during DILI at the subcellular organelle level.
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