If the lymphocyte count is still low enough, the first part of the wait-and-see approach for asymptomatic Rai stage 0 classical B-CLL can be used to find out if the lymphocyte counts follow an exponential growth curve. If they do, the whole food, plant-based (WFPB) diet intervention can be started.
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http://dx.doi.org/10.1002/ccr3.3305 | DOI Listing |
Int J Biol Macromol
January 2025
Institute of Hybrid Materials, National Center of International Research for Hybrid Materials Technology, National Base of International Science & Technology Cooperation, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. Electronic address:
Bacterial infections and excessive accumulation of wound exudates remain the main obstacles and clinical challenges to the healing of chronic cutaneous wounds. Conventional dressings are commonly used medical materials for acute wound care, but they do not possess the bacterial infection resistance required for chronic wound treatment. Herein, we prepared pure chitosan nanofibrous membranes (C) by electrospinning with poly(ethylene oxide) (PEO) as a sacrificial additive and then loaded with zinc-based metal-organic framework (MOF) as a novel antimicrobial wound dressing.
View Article and Find Full Text PDFEur J Pharm Sci
January 2025
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111, Budapest, Hungary. Electronic address:
The development of stable biopharmaceutical formulations, such as monoclonal antibodies, poses a great challenge in the pharmaceutical industry. This study investigated the stabilizing effect of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in liquid and solid formulations of infliximab during processing and storage. The solid formulation was produced by a scaled-up high-speed electrospinning method, resulting in a product suitable for reconstitution with excellent dissolution properties.
View Article and Find Full Text PDFUrology
January 2025
S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Objectives: To evaluate the impact of Aquablation on circulating tumor cells (CTCs) in men with localized prostate cancer.
Methods: This prospective study included subjects with biopsy-positive mpMRI visible lesions (PIRADS ≥ 3) who underwent Aquablation. Ten ml blood samples were collected before, during and after the procedure to measure CTC counts using an immunofluorescence assay.
Cell Metab
January 2025
Henan Academy of Sciences, Zhengzhou 450000, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and aging-related disorders, making them potential targets for anti-aging interventions. In this study, we demonstrated that human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro.
View Article and Find Full Text PDFJ Mol Graph Model
January 2025
Institute of Chemical Physics after A.B. Nalbandyan of NAS RA, 5/2 P. Sevak St., Yerevan, 0014, Armenia.
Liquid crystals (LC) are widely used in various optical devices due to their birefringence, dielectric anisotropy, and responsive behavior to external fields. Enhancing the properties of existing LCs through doping with nanoparticles, including semiconductor quantum dots, offers a promising route for improving their performance. Among various nanoparticles, QDs stand out for their high charge mobility, sensitivity in the near-infrared spectral region, and cost-effectiveness.
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