Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences.

Proc Math Phys Eng Sci

Surgical Robotics Laboratory, Department of Biomechanical Engineering, University of Twente, 7522 NB Enschede, The Netherlands.

Published: November 2020

Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735305PMC
http://dx.doi.org/10.1098/rspa.2020.0621DOI Listing

Publication Analysis

Top Keywords

actuation techniques
8
manipulation
6
contactless acoustic
4
acoustic micro/nano
4
micro/nano manipulation
4
manipulation paradigm
4
paradigm generation
4
generation applications
4
applications life
4
life sciences
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!