The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410 | PMC |
| http://dx.doi.org/10.1016/j.medj.2020.12.001 | DOI Listing |
Publication Analysis
Top Keywords
life-threatening covid-19
8
covid-19 defective
4
defective interferons
4
interferons unleash
4
unleash excessive
4
excessive inflammation
4
inflammation risk
4
risk life-threatening
4
covid-19 pneumonia
4
pneumonia increases
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!