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Secular trends of physical fitness for college students in Anhui Province over the past decade.
BMC Public Health
January 2025
School of Physical Education, Chizhou University, Chizhou, 247000, China.
Background: Since the beginning of the 21st century, China's economy has experienced rapid growth, resulting in a steady improvement in its citizens' living standards. However, alongside the emergence of modern civilization-related health issues, the overall physical fitness of the population has been declining. In the final year of 2019, a global COVID-19 pandemic emerged and persisted for three years, causing a significant diminution in human physical well-being.
View Article and Find Full Text PDFRole of PEGylated lipid in lipid nanoparticle formulation for in vitro and in vivo delivery of mRNA vaccines.
J Control Release
January 2025
Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Republic of Singapore. Electronic address:
mRNA-loaded lipid nanoparticles (mRNA-LNPs) hold great potential for disease treatment and prevention. LNPs are normally made from four lipids including ionizable lipid, helper lipid, cholesterol, and PEGylated lipid (PEG-lipid). Although PEG-lipid has the lowest content, it plays a crucial role in the effective delivery of mRNA-LNPs.
View Article and Find Full Text PDFFormulation screening of lyophilized mRNA-lipid nanoparticles.
Int J Pharm
January 2025
Department of Pharmaceutics, Institute of Pharmaceutical Sciences, University of Freiburg, Sonnenstr. 5, Freiburg i. Br. 79104 Germany; ten23 health AG, Mattenstr. 22, Basel 4058 Switzerland. Electronic address:
Lipid nanoparticles (LNPs) have demonstrated their therapeutic potential as safe and effective drug delivery systems for nucleic acids during the COVID-19 pandemic. However, one of the main challenges during technical CMC (Chemistry, Manufacturing, and Controls) development is their long-term stability at temperatures of 2-8 °C or higher, which may be improved by the removal of water by lyophilization. In this study, we identified lyo-/cryo-protectants for freeze-dried mRNA-LNP formulations beyond conventional excipients such as sucrose and trehalose as T-modifiers using polyA as a surrogate.
View Article and Find Full Text PDFPrognostic significance of cytokine dysregulation in critically ill COVID-19 patients.
Cytokine
January 2025
Multidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista 45029-094, Bahia, Brazil. Electronic address:
Background: Understanding the immunopathogenesis of COVID-19 has yielded valuable insights into predicting adverse outcomes-particularly mortality. However, significant gaps persist in our comprehension of the complex interplay among the proposed pathophysiological mechanisms. Here, we aim to investigate the immunological factors associated with mortality in critically ill, unvaccinated COVID-19 patients admitted to the intensive care unit (ICU).
View Article and Find Full Text PDFPopulation-level impact of COVID-19 on thyroid function tests: Results from a repeated cross-sectional study.
J Infect Public Health
January 2025
Department of Genomic Medicine, Division of Biochemistry, Molecular Biology, and Nutrition, University Hospital of Nancy, Nancy F-54000, France; Reference Center for Inborn Errors of Metabolism (ORPHA67872), University Hospital of Nancy, Nancy F-54000, France; Faculty of Medicine of Nancy, University of Lorraine, Nancy F-54000, France; INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Nancy F-54000, France. Electronic address:
Purpose: Reports have highlighted thyroid abnormalities, including subacute thyroiditis and thyrotoxicosis, in COVID-19 patients, with a potential link between thyroid dysfunction and disease severity. However, population-level studies on COVID-19's impact on thyroid hormone levels are limited. We aimed to assess the impact of the COVID-19 pandemic on thyroid function tests at the population level.
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