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Comparative transcriptomics pinpoints conserved and specific transcriptional responses to phosphorus limitation.
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Noble Research Institute, Ardmore, OK 73401, USA.
Translating biological knowledge from Arabidopsis to crop species is important to advance agriculture and secure food production in the face of dwindling fertilizer resources and biotic and abiotic stresses. However, it is often not trivial to identify functional homologs (orthologs) of Arabidopsis genes in crops. Combining sequence and expression data can improve the correct prediction of orthologs.
View Article and Find Full Text PDFBackground: Visuospatial problems are one of the possible signs of Alzheimer's Disease (AD). Notably, various studies on eye movement in static image searches reveal that individuals with dementia fixate on fewer Areas of Interest (AoIs) for a significantly shorter duration than normal controls (CTLs). Building on prior works on speech and eye movement, in this study we examined word timestamps to infer each subject's focus of attention while describing the Cookie Theft picture.
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December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Sex is an important factor that contributes to both clinical and biological heterogeneity in Alzheimer's disease (AD), but the regulatory mechanisms underlying sex differences in AD are still not well understood. DNA methylation (DNAm) is an epigenetic modification that regulates gene transcription and is known to be involved in AD. However, due to analytical and biological complexity, few previous DNAm studies analyzed the X chromosome, where many genes influencing cognitive abilities and immune functions are located.
View Article and Find Full Text PDFBackground: There is a critical need for minimally-invasive robust peripheral markers of neurodegenerative conditions. Peripheral RNA may be a powerful tool for in-depth tracking of biological processes in AD and related disorders. Here, we combine whole-blood microarray data from Alzheimer's Disease Neuroimaging Initiative (ADNI; N=743) and RNA-Seq from Translational Biomarkers in Aging and Dementia (TRIAD; N=77) and Montreal Neurological Institute (MNI; N=33) cohorts to predict cognitive performance across AD spectrum.
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Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Background: Epigenetics plays a crucial role in regulating genetic transcription and responding to environmental and lifestyle changes without altering the DNA sequence. Their dysregulation is associated with AD, presenting potential as blood biomarkers. However, no study has evaluated whether peripheral blood (PB) epigenetic biomarkers are associated with brain metabolism, indexed by FDG-PET, a classic Imaging AD biomarker.
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