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Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events.
J Immunother Cancer
October 2024
Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah University Medical Center Division of Internal Medicine, Jerusalem, Israel.
Article Synopsis
- Immune checkpoint inhibitors (ICI) for cancer like pembrolizumab and nivolumab can lead to immune-related adverse events (Eo-irAE), including high eosinophil levels that may predict positive treatment responses but can also cause significant organ dysfunction.
- This study evaluates the use of interleukin (IL) 5-axis inhibition to treat Eo-irAE, using medications like mepolizumab and benralizumab in three patients who developed these adverse effects after ICI therapy.
- Results showed rapid improvement in symptoms and a reduction in eosinophil levels with no negative impacts from the IL-5 targeted treatments, indicating they can be effective in managing Eo-irAE in cancer patients undergoing ICI
Systemic sclerosis with morphea-like plaques histopathologically mimicking cutaneous B-cell lymphoma.
JAAD Case Rep
May 2024
Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.
Pathological nerve patterns in human basal cell carcinoma.
Eur J Dermatol
June 2021
Clinical Neurophysiology Unit, Istituti Clinici Scientifici Maugeri SB SpA IRCCS, Via Salvatore Maugeri 10, 27100 Pavia, Italy.
The peculiar combined, or binary involvement of epithelium and stroma makes basal cell carcinoma (BCC) a unique tumour. Nerve fibres have been shown to play an active role in different cancers. A prospective observational study was carried out on punch biopsies harvested within BCC surgical excision specimens.
View Article and Find Full Text PDFMorphea-Like Carcinoma En Cuirasse Revealing a Bilateral Breast Cancer.
Am J Med
June 2021
Department of Pathology, Farhad Hachad Hospital, Sousse, Tunisia.
BASAL CELL CARCINOMA OF THE FOOT - TWO CASE REPORTS AND LITERATURE REVIEW.
Georgian Med News
March 2018
Department of Dermatology and Allergology, Dresden Municipal Hospital, Academic Teaching Hospital of the Technical University, Dresden, Germany; Institute of Pathology "Georg Schmorl", Dresden Municipal Hospital, Academic Teaching Hospital of the Technical University, Dresden, Germany.
Basal cell carcinoma (BCC) is considered the most common skin cancer in men. BCC of the foot, however, is very rare, and may occur on dorsal surface of the foot, foot sole or nail apparatus. Diagnosis is often delayed due to the location at an unusual site.
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