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Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment. | LitMetric

AI Article Synopsis

  • Doxorubicin (DOX) is effective against lung cancer but causes harmful side effects, including oxidative stress and inflammation.
  • Luteolin (LUT), a compound found in fruits and vegetables, shows promise in reducing these negative effects when co-administered with DOX in a study involving male Wistar rats.
  • The study revealed that LUT improved overall health, blood cell counts, and lung function while reducing inflammation and oxidative damage caused by DOX, suggesting that combining LUT with DOX chemotherapy could help minimize toxic side effects in patients.

Article Abstract

Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and vegetables is pharmacologically active against oxido-inflammatory and apoptotic responses. The present study examined the effect of LUT on DOX-induced lungs and blood dysfunction in Wistars rat (sex: male; 10 weeks old, 160 ± 5 g). Randomly grouped (n = 10) rats were treated as follows: control, LUT alone (100 mg/kg; per os), DOX (2 mg/kg; i. p), and co-treated rats with LUT (50 or 100 mg/kg) and DOX for two consecutive weeks. DOX alone adversely altered the final body and relative organ weights, red and white blood cell and platelet counts. DOX significantly (p > 0.05) reduced lungs antioxidant capacity, and anti-inflammatory cytokines; increased biomarkers of oxidative stress, caspase-3 activity, and pro-inflammatory cytokine. Morphological damages accompanied these biochemical alterations in the lung of experimental rats. Co-treatment with LUT, dose-dependently reversed DOX-mediated changes in rats' survival, toxic responses, and diminished oxidative stress in rat's lungs. Furthermore, co-treatment with LUT resulted in the reduction of pro-inflammatory cytokines and apoptotic biomarkers, increased red and white blood cell, platelet counts and abated pathological injuries in rat lungs treated with DOX alone. In essence, our findings indicate that LUT dose-dependently mitigated DOX-induced toxicities in the lungs and haematopoietic systems. Supplementation of patients on DOX-chemotherapy with phytochemicals exhibiting antioxidant activities, specifically LUT, could circumvent the onset of unintended toxic responses in the lungs and haematopoietic system exposed to DOX.

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Source
http://dx.doi.org/10.1016/j.taap.2020.115380DOI Listing

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