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Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.
J Neuroendocrinol
December 2024
Douglas Mental Health University Institute Research Center, Montreal, Quebec, Canada.
Being raised under adverse conditions during infancy and childhood represents a significant risk factor for developing later psychopathologies and dysfunctions in emotional, affective, and cognitive abilities. Depending on the type, timing, and duration of early adversity, different consequences emerge across the sexes in both human and animal models, although our understanding of the underlying interactions between sex and early life stress (ELS) is still incomplete. In this study, we used the limited bedding (LB) paradigm, a well-described model of ELS in rat pups during the first 10 days of life, and tested whether masculinization of the female brain by neonatal injections of estradiol benzoate (EB) would recapitulate the ELS-induced vulnerability phenotype of males on morphology of the basolateral amygdala (BLA) principal neurons and pre-adolescent and adult behavior.
View Article and Find Full Text PDFBradycardia, Renal Failure, Atrioventricular (AV) Nodal Blockers, Shock, and Hyperkalemia (BRASH) Syndrome: A Confounder in the Clinical Practice.
Cureus
October 2024
Internal Medicine, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Chaves, PRT.
BRASH, an acronym for Bradycardia, Renal failure, AV nodal blockers, Shock, and Hyperkalemia, syndrome is a clinical synergic phenomenon that can result in cardiovascular collapse. We present the case of an 83-year-old woman with dilated cardiomyopathy, heart failure, and chronic kidney disease who was admitted to the emergency room due to syncope and a worsening general condition. The patient was on several medications, including carvedilol, a beta-blocker.
View Article and Find Full Text PDFUnderstanding the synergistic sensitization of natural products and antibiotics: An effective strategy to combat MRSA.
Eur J Med Chem
January 2025
Guangzhou 11th People's Hospital, Guangzhou Cadre and Talent Health Management Center, Guangzhou, PR China. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multi-resistant organisms found in hospital-acquired infections and is associated with high morbidity and mortality. The development of new drugs and promising therapeutic strategies against MRSA is thus an urgent request. In recent years, some natural products have been demonstrated to show great potential in improving the efficacy of antibiotics to treat various drug-resistant bacteria, particularly MRSA.
View Article and Find Full Text PDFBackground: Global pandemics like COVID-19 put a high amount of strain on health care systems and health workers worldwide. These crises generate a vast amount of news information published online across the globe. This extensive corpus of articles has the potential to provide valuable insights into the nature of ongoing events and guide interventions and policies.
View Article and Find Full Text PDFThe glycoprotein hormone receptor (LGR1) influences Malpighian tubule secretion rate in Rhodnius prolixus.
J Exp Biol
December 2024
Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada, L5L 1C6.
In the hemipteran Rhodnius prolixus, successful post-prandial diuresis is accomplished through the synergistic actions of the peptidergic diuretic hormone RhoprCRF/DH and the biogenic amine 5-hydroxytryptamine (5-HT), and by an antidiuretic hormone RhoprCAPA-2 that terminates diuresis by inhibiting this synergy. Lateral neurosecretory cells (NSCs) in the mesothoracic ganglionic mass release RhoprCRF/DH, while midline NSCs release RhoprCAPA-2 during blood feeding. These NSCs co-express GPA2/GPB5, a conserved glycoprotein hormone involved in various physiological processes across bilaterians.
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