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POLYPHARMACY AND CANCER: А NEW VISION FOR SKIN CANCER PATHOGENESIS-PHOTOTOXICITY AND PHOTOCARCINOGENICITY DUE TO NITROSAMINE CONTAMINATION DURING TELMISARTAN/ TAMSULOSIN INTAKE.
Georgian Med News
November 2024
4Department of Pathology, University of Virginia, Charlottesville, USA.
The toxicokinetics of nitrosamines remain a mystery to this day, though it appears that the role of nitrosamines in potentiating the generation of mutations required for the onset of skin cancer continues to be a significant concern. Nitrosamines are mutagens, genotoxic substances, and mediators of phototoxicity/carcinogenicity, whose long-term daily usage, in the context of polypharmacy, can result in the parallel appearance of heterogeneous forms of skin cancer: keratinocytic and melanocytic. But a number of clinical observations suggest that it is the nitrosamines that potentiate the multiple occurrences of skin cancer over the years, or recurrences of skin cancer localized in areas exposed to solar radiation.
View Article and Find Full Text PDFEducation Research: Making a Tweetorial Fly: Features of Educational Social Media Posts Associated With High Sharing and Engagement.
Neurol Educ
December 2024
From the Departments of Neurology and Neurosurgery (C.S.W.A., E.C.L.), Emory University School of Medicine, Atlanta, GA; Division of Biostatistics (T.M.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (G.F.P.), University of Pittsburgh, PA; Department of Neurology (A.S.Z.), Weill Cornell Medical College, New York, NY; Emory University School of Medicine (N.D.), Atlanta, GA; Consulting Web Developer (S.M.), Scotland; Department of Neurology (A.S.), Wake Forest University, Winston-Salem, NC; Departments of Neurology and Neurosurgery (N.S.D), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Neurology (A.L.B.), University of California, San Francisco; Department of Neurology (N.A.M.), University of Maryland School of Medicine, Baltimore, MD; and Department of Neurology (L.K.J.), Mayo Clinic, Rochester, MN.
Background And Objectives: Social media platforms such as X (formerly Twitter) are increasingly used in medical education. Characteristics of tweetorials (threaded teaching posts) associated with higher degrees of engagement are unknown. We sought to understand features of neurology-themed tweetorials associated with high sharing and engagement.
View Article and Find Full Text PDFLocally advanced non-small cell lung cancer: search for the optimal radiotherapy continues.
Transl Cancer Res
December 2024
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Human leukocyte antigen and donor-specific antibodies in liver transplantation.
World J Gastroenterol
January 2025
Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
In this article, we comment on an article published in a recent issue of the . We specifically focus on the roles of human leukocyte antigen (HLA) and donor-specific antibodies (DSAs) in pediatric liver transplantation (LT), as well as the relationship between immune rejection after LT and DSA. Currently, LT remains the standard of care for pediatric patients with end-stage liver disease or severe acute liver failure.
View Article and Find Full Text PDFContinuous Adductor Canal Block Compared to Epidural Anesthesia for Total Knee Arthroplasty [Response to Letter].
J Pain Res
January 2025
Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
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