The earth is currently facing an unprecedented biodiversity loss, which is taking such proportions that it is sometimes considered to be the sixth mass extinction. Human activities are the main cause of this alarming ecological crisis and threaten this biodiversity yet essential to mankind. It is thus necessary to learn more about the different living species, in order to protect and preserve them. In particular, three key scientific fields give us a better insight on biodiversity and its characteristics: ecology, focusing on living species interacting with their environment; ethology, focusing on animal behaviour; and ecophysiology, linking changes at the physiological scale to environmental changes. Together, they allow us to work in favor of biodiversity, by giving us a better understanding of animal species and their ways of life, thus allowing us to act accordingly.
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http://dx.doi.org/10.1051/jbio/2020013 | DOI Listing |
Nucleic Acids Res
January 2025
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning 530004, China.
Copper (Cu), a trace element with redox activity, is both essential and toxic to living organisms. Its redox properties make it a cofactor for a variety of proteins, but it also causes oxidative stress, hence the need to maintain intracellular copper homeostasis. However, the role of copper in the regulation of antioxidant defense in bacteria remains unclear, and the involved transcription factors remain to be explored.
View Article and Find Full Text PDFGenome Biol Evol
December 2024
Living Earth Collaborative, Washington University in St. Louis, St. Louis, MO 63130, USA.
In the context of evolutionary time, cities are an extremely recent development. Although our understanding of how urbanization alters ecosystems is well-developed, empirical work examining the consequences of urbanization on adaptive evolution remains limited. To facilitate future work, we offer candidate genes for one of the most prominent urban carnivores across North America.
View Article and Find Full Text PDFBackground: VY-TAU01 is a recombinant humanized IgG4 monoclonal antibody (mAb) directed against pathological tau for the treatment of patients with mild dementia or mild cognitive impairment due to Alzheimer's disease (AD). Both VY-TAU01 and its parental mouse IgG1 mAb Ab-01 target an epitope in the C-terminus of tau, bind pathological tau with high affinity and selectivity over wild-type tau, block paired helical filament seed-induced tau aggregates in vitro, and selectively stain tau tangles in AD and P301S mouse (C57/B6J-Tg[Thy1-MAPT*P301S]2541Godt) brain. Ab-01 robustly inhibits seeding and propagation of pathological tau in a P301S mouse seeding model.
View Article and Find Full Text PDFRedox Biochem Chem
December 2024
Department of Biophysics, Medical College of Wisconsin, Milwaukee, United States.
Peroxynitrite (ONOO/ONOOH) is a short-lived but highly reactive species that is formed in the diffusion-controlled reaction between nitric oxide and the superoxide radical anion. It can oxidize certain biomolecules and has been considered as a key cellular oxidant formed under various pathophysiological conditions. It is crucial to selectively detect and quantify ONOO to determine its role in biological processes.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
January 2025
Georgina Mace Centre for the Living Planet, Silwood Park, Ascot SL5 7PY, UK.
Current rates of habitat and biodiversity loss, and the threat they pose to ecological and economic productivity, would be considered a global emergency even if they were not occurring during a period of rapid anthropogenic climate change. Diversity at all levels of biological organization, both within and among species, and across genomes and communities, is critical for the resilience of the world's ecosystems in the face of such change. However, it remains an urgent scientific challenge to understand how biodiversity underpins these ecological outputs, how patterns of biodiversity are being affected by current threats, and how and where such biodiversity contributes most directly to human economies, well-being and social justice.
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