AI Article Synopsis
- Ovarian cancer is a serious health issue in the U.S. with limited treatments for advanced stages, making it the deadliest gynecologic cancer.
- Mesothelin, a protein found in ovarian cancer cells, is a target for new antibody-drug conjugates that show promise as new therapies.
- Current studies, including preclinical and early clinical trials, indicate these mesothelin-targeting treatments have potential benefits and manageable side effects, but further phase III trials are needed to confirm their effectiveness in more advanced cases.
Article Abstract
Ovarian cancer is the deadliest gynecologic malignancy in the United States, and effective therapies for recurrent, advanced, and progressive disease are limited. Mesothelin is known to be expressed in ovarian cancers, and antibody-drug conjugates targeting mesothelin are a promising novel therapeutic agent. This article reviews the currently available literature of anti-mesothelin antibody-drug conjugates as a novel treatment for ovarian cancer. Preclinical in vitro and in vivo data as well as clinical results are reviewed for each available agent. Additionally, adverse effects are covered. Anti-mesothelin antibody-drug conjugates and their combination with chemotherapeutic agents have undergone phase II trials with encouraging results and demonstrated favorable adverse effect profiles. Phase III data will be necessary to establish its role in ovarian cancer, particularly in recurrent, advanced, or progressive disease.
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| http://dx.doi.org/10.1080/14712598.2021.1869210 | DOI Listing |
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