Purpose: In an osteoporotic vertebral body, cement-augmented pedicle screw fixation could possibly be optimized by the creation of an initial cavity. The aim of this study is to compare three test groups with regard to their loosening characteristics under cyclic loading.
Methods: Eighteen human, osteoporotic spine segments were divided in three groups. Flexibility tests and cyclic loading tests were performed with an internal fixator. The screws were fixed after creation a cavity and with cement (cavity-augmented group), without cavity and with cement (augmented group), and without cavity and without cement (control group). Cyclic loading up to 100,000 cycles was applied with a complex loading protocol. Screw loosening was measured with flexibility tests after implantation and after cyclic loading. Cement distribution was visualized from CT scans.
Results: In all groups, range of motion increased during cyclic loading, representing significant screw loosening after 100,000 cycles. In both augmented groups, screw loosening was less pronounced than in the control group. The cavity-augmented group showed only a slight tendency of screw loosening, but with smaller variations compared to both other groups. This may be explained with a trend for a more equal and homogeneous cement volume around each tip for the cavity-augmented group.
Conclusion: This study demonstrated that creating a cavity may allow a more equal fixation of all pedicle screws with slight reduction of loosening. However, augmentation only through a cannulated screw is almost equivalent, if care is taken that enough cement volume can be pushed out around the tip of the screw.
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Sci Rep
January 2025
School of Railway Engineering, Hunan Technical College of Railway High-Speed, Hengyang, 421002, China.
Research on the evolutionary behavior of the particle breakage processes in coarse-grained soil under the action of train load is of practical significance for subgrade construction and maintenance. However, existing studies have not addressed the prediction of particle size distribution evolution. In this paper, the MTS loading system is used to simulate the dynamic train load effect on coarse-grained soil fillers.
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January 2025
School of Geomatics and Prospecting Engineering, Jilin Jianzhu University, Changchun, 130118, China.
The new type of support disc-type anchor is an expanded body anchor with broad application prospects, and its load-bearing performance is significantly better than that of traditional anchors. However, there is a problem of premature shear damage in traditional support disc-type anchors. In order to solve this problem, this paper improves the traditional support disk anchor.
View Article and Find Full Text PDFNat Commun
January 2025
Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.
Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity. Following pulmonary delivery, the nanovesicles rapidly accumulate in the lung and selectively deliver STING agonists to PD-L1-overexpressing cells via the PD-1/PD-L1 interaction.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
State Key Laboratory Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Road South, Nanjing 211816, China.
The cycloaddition of CO to epoxide (CCE) reactions produce valuable cyclic carbonates useful in the electrolytes of lithium-ion batteries, as organic solvents, and in polymeric materials. However, halide-containing catalysts are predominantly used in these reactions, despite halides being notoriously corrosive to steel processing equipment and residual halides also having harmful effects. To eliminate the reliance on halides as cocatalyst in most CCE reactions, halide-free catalysts are highly desirable.
View Article and Find Full Text PDFACS Omega
December 2024
Departamento de Química, Instituto Tecnológico de Aeronáutica, São José dos Campos, São Paulo CEP 12228-900, Brazil.
The five-coordinate complex [RuCl(PNP)] () was synthesized from the binuclear [RuCl(-cym)] with a PNP-type ligand (PNP = 3,6-di--butyl-1,8-bis(dipropylphosphino)methyl)-9-carbazole - (Cbzdiphos )H) in a toluene solution, within 20 h at 110 °C, producing a green solid, which was precipitated with a 1/1 mixture of - pentane/HMDSO. The complex was characterized by NMR-H, C, and P{H}, mass spectroscopy-LIFDI, FTIR, UV/vis spectroscopy, and cyclic voltammetry, as well as a description of the optimized structure by DFT calculation. The reactivity of was investigated in the presence of potassium triethylborohydride (KBEtH, in THF solution of 1.
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