COVID-19 strongly hit healthcare organizations due to three factors: the lack of knowledge of this new virus, the fear of the people, and the continuous modifications in the management of the crisis. This situation required flexibility and adaptability of organizations, as our university health centre demonstrated. It relied on a decentralized model of management based on three pillars: a culture of innovation and creativity, an agile organizational structure, and an open innovation ecosystem and network. These assets were already developed prior to the onset of COVID-19 and helped our organization to better respond to the crisis.
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http://dx.doi.org/10.1177/0840470420980478 | DOI Listing |
Neuro Oncol
January 2025
Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen; Tübingen, Germany.
Background: Registered systemic treatment options for glioblastoma patients are limited. The phase II REGOMA trial suggested an improvement of median overall survival in progressive glioblastoma by the multi-tyrosine kinase inhibitor regorafenib. This has not been confirmed by GBM AGILE.
View Article and Find Full Text PDFThe built and natural environment can facilitate (un)healthy behaviors in adolescence. However, most previous studies have focused on examining associations between singular aspects of the environment. This study examined the association between the mixture of health-promoting and health-constraining environmental features in a Healthy Location Index (HLI) and physical activity and screen time among adolescents.
View Article and Find Full Text PDFScience
January 2025
Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the circumsporozoite protein (PfCSP). Here, using an antigen-agnostic strategy to investigate human antibody responses to whole sporozoites, we identified a class of mAbs that target a cryptic PfCSP epitope that is only exposed after cleavage and subsequent pyroglutamylation (pGlu) of the newly formed N terminus. This pGlu-CSP epitope is not targeted by current anti-PfCSP mAbs and is not included in the licensed malaria vaccines.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
Department of Electrical and Computer Engineering, Hellenic Mediterranean University, GR-71410 Heraklion, Greece.
Front Artif Intell
December 2024
Universidad Latinoamérica de Ciencia y Tecnología (ULACIT), San José, Costa Rica.
The COVID-19 pandemic marked a before and after in the business world, causing a growing demand for applications that streamline operations, reduce delivery times and costs, and improve the quality of products. In this context, artificial intelligence (AI) has taken a relevant role in improving these processes, since it incorporates mathematical models that allow analyzing the logical structure of the systems to detect and reduce errors or failures in real-time. This study aimed to determine the most relevant aspects to be considered for detecting software defects using AI.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!