AI Article Synopsis
- Regulated cell death (RCD) is essential in determining how severe and damaging liver injuries can be, particularly impacting liver diseases through inflammation and fibrosis.
- Various cell death processes, such as apoptosis, necrosis, and newer ones like pyroptosis and ferroptosis, have been studied for their roles in liver disease, showing both unique and overlapping traits.
- The review highlights the signaling pathways involved in each cell death type and discusses findings, controversies, and limitations in research related to liver damage from conditions like alcoholic liver disease and viral hepatitis.
Article Abstract
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury. Hepatocyte cell death is a critical event in the progression of liver disease due to resultant inflammation leading to fibrosis. Apoptosis, necrosis, necroptosis, autophagy, and recently, pyroptosis and ferroptosis, have all been investigated in the pathogenesis of various liver diseases. These cell death subroutines display distinct features, while sharing many similar characteristics with considerable overlap and crosstalk. Multiple types of cell death modes can likely coexist, and the death of different liver cell populations may contribute to liver injury in each type of disease. This review addresses the known signaling cascades in each cell death pathway and its implications in liver disease. In this review, we describe the common findings in each disease model, as well as the controversies and the limitations of current data with a particular focus on cell death-related research in humans and in rodent models of alcoholic liver disease, non-alcoholic fatty liver disease and steatohepatitis (NASH/NAFLD), acetaminophen (APAP)-induced hepatotoxicity, autoimmune hepatitis, cholestatic liver disease, and viral hepatitis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766597 | PMC |
| http://dx.doi.org/10.3390/ijms21249682 | DOI Listing |
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