AI Article Synopsis
- - Graphene quantum dots (GQDs) are a promising material in nanotechnology due to their advanced properties but can face challenges in reactions typically performed in organic solvents due to their hydrophilic nature.
- - The study explored 1,3-dipolar cycloaddition reactions involving specific nitrone compounds and GQDs, successfully producing unique cycloadducts under eco-friendly conditions using a natural deep eutectic solvent (NADES).
- - This research is significant as it demonstrates for the first time that cycloaddition reactions can occur directly on the surface of GQDs, highlighting the advantages of using green solvents which enhance solubility and interact well with aromatic systems.
Article Abstract
Due to their outstanding physicochemical properties, the next generation of the graphene family-graphene quantum dots (GQDs)-are at the cutting edge of nanotechnology development. GQDs generally possess many hydrophilic functionalities which allow their dispersibility in water but, on the other hand, could interfere with reactions that are mainly performed in organic solvents, as for cycloaddition reactions. We investigated the 1,3-dipolar cycloaddition (1,3-DCA) reactions of the C-ethoxycarbonyl -methyl nitrone and the newly synthesized -diethoxyphosphorylpropilidene -benzyl nitrone with the surface of GQDs, affording the isoxazolidine cycloadducts -GQDs and -GQDs . Reactions were performed in mild and eco-friendly conditions, through the use of a natural deep eutectic solvent (NADES), free of chloride or any metal ions in its composition, and formed by the zwitterionic trimethylglycine as the -bond acceptor, and glycolic acid as the hydrogen-bond donor. The results reported in this study have for the first time proved the possibility of performing cycloaddition reactions directly to the p-cloud of the GQDs surface. The use of DES for the cycloaddition reactions on GQDs, other than to improve the solubility of reactants, has been shown to bring additional advantages because of the great affinity of these green solvents with aromatic systems.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765906 | PMC |
| http://dx.doi.org/10.3390/nano10122549 | DOI Listing |
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