Objective: The biological mechanisms of cryotherapy for managing acute pain remain unclear. Additionally, it is unknown whether the effectiveness of cryotherapy depends on the applied temperature. This study aimed to clarify the biological effects of cryotherapy and to examine the therapeutic effects of cryotherapy applied at different temperatures in rats.
Methods: This was an experimental study using a rat knee joint arthritis model. Thirty-five Wistar rats were randomly divided into arthritis (AR), arthritis with 5°C cryotherapy (CR-5), arthritis with 10°C cryotherapy (CR-10), and sham-arthritis control (CON) groups. Arthritis was induced by injecting a mixture of kaolin/carrageenan into the right knee joint. Cryotherapy was applied for 7 days starting the day after injection by immersing the right knee joint in 5°C or 10°C water. Joint transverse diameter, pressure pain threshold, and pain-related behaviors were assessed for 7 days. The number of CD68-positive cells in the knee joint and the expression of calcitonin gene-related peptide in the spinal dorsal horn 8 days after injection were analyzed by immunohistochemical staining.
Results: Improvements in transverse diameter, pressure pain threshold, and pain-related behaviors were observed in the CR-5 and CR-10 groups on the 3rd day compared with the AR group. The number of CD68-positive cells and the expression of calcitonin gene-related peptide in the CR-5 and CR-10 groups were significantly decreased compared with the AR group. There were no significant differences in all results between the CR-5 and CR-10 groups.
Conclusions: Cryotherapy can ameliorate inflammatory pain through reduction of synovium and central sensitization. Additionally, the effects of cryotherapy lower than 10°C are observed independent of applied temperature.
Impact: Cryotherapy may be beneficial as a physical therapy modality for pain and swelling management in the acute phase of inflammation. Translational human study is needed to determine the effective cryotherapy temperature for the inflammatory pain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ptj/pzaa211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Daylight Photodynamic Therapy: At-Home Delivery.
J Clin Med
December 2024
School of Medicine, University of Dundee, Dundee DD1 4HN, UK.
This pilot study evaluated the design, usability, and practicality of the dPDT@home kit for treating actinic keratoses (AKs) on the face and scalp. The kit allowed patients to manage their treatment at home, reducing hospital visits and utilizing natural sunlight. While patients were very willing to use the kit again, further studies are required to evaluate outcomes and ascertain the need for additional improvements and support.
View Article and Find Full Text PDFWhole-Body Cold Stimulation Improves Cardiac Autonomic Control Independently of the Employed Temperature.
J Clin Med
December 2024
BIOMETRA Department, University of Milan, 20129 Milan, Italy.
: The autonomic nervous system (ANS) is considered one of the mechanisms mediating the benefits of whole-body cold stimulation (WBC). Nevertheless, different treatment protocols, different methodologies employed to assess the ANS, and, in particular, difficulties in interpreting the numerous variables obtained represent important barriers to understanding the effects of WBC on the ANS. The present study aimed to explore the effects of WBC on cardiac autonomic control (CAR) as assessed using a single composite percentile-ranked proxy of autonomic balance (ANSI), considering two different WBC temperatures and the same WBC protocol.
View Article and Find Full Text PDFThe Effect of Physiotherapy on Arthrogenic Muscle Inhibition After ACL Injury or Reconstruction: A Systematic Review.
Life (Basel)
December 2024
CESPU, Instituto Politécnico de Saúde do Norte, Escola Superior de Saúde do Vale do Ave, 4760-409 Vila Nova de Famalicão, Portugal.
Arthrogenic muscle inhibition (AMI) following ACL injury or reconstruction is a common issue that affects muscle activation and functional recovery. Thus, the objective of this study was to systematize the literature on the effects of physiotherapy interventions in the rehabilitation of AMI after ACL injury or reconstruction. A systematic review was conducted following the PRISMA guidelines.
View Article and Find Full Text PDFWearable Fluidic Fabric with Excellent Heat Transfer Performance for Sports Recovery.
Adv Sci (Weinh)
January 2025
Research Institute for Intelligent Wearable Systems, School of Fashion and Textiles, The Hong Kong Polytechnic University, Kowloon, 999077, China.
Rapid temperature contrast hydrotherapy by water immersion has been utilized by athletes for effective sports recovery. However, its application at some training or competition venues is limited by high water consumption, bucky size, personal hygiene, and inconvenience. Here, a novel portable system equipped with highly effective, lightweight, and hygienic wearable fluidic fabric device is reported, that replaces direct water immersion.
View Article and Find Full Text PDFApplication of multifunctional pulse wave sphygmomanometer combined with constant temperature ice in patients with forearm hematoma after coronary intervention.
BMC Cardiovasc Disord
January 2025
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Aim: This study aims to investigate the effects of combining a multifunctional pulse wave sphygmomanometer with constant temperature ice on patients with forearm hematoma following coronary intervention.
Methods: Patients who developed forearm hematoma after undergoing coronary intervention from March 2021 to March 2023 at our hospital were selected as the study cohort. Using a random number table, they were divided into two groups the control group and the research group.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!