A phylogenomic analysis based on 107 single-copy core genes revealed that three strains from sugar-rich environments, i.e. LMG 1728, LMG 1731 and LMG 22058, represented a single, novel lineage with as nearest validly named neighbour. OrthoANIu and digital DNA-DNA hybridization analyses among these strains and type strains confirmed that the three strains represented a novel species. Biochemical characteristics and MALDI-TOF mass spectra allowed differentiation of this novel species from the type strains of and other closely related species. We therefore propose to classify strains LMG 1728, LMG 1731 and LMG 22058 in the novel species sp. nov., with LMG 1728 (=CECT 30142) as the type strain.
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http://dx.doi.org/10.1099/ijsem.0.004569 | DOI Listing |
Arterioscler Thromb Vasc Biol
January 2025
British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, United Kingdom. (M.W., M.F., R.O., L.S., M.M., C.M.S.).
Background: The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs). Aging and disease are associated with dramatic changes in ECM composition and properties; however, their impact on the VSMC phenotype remains poorly studied.
Methods: Here, we describe a novel in vitro model system that utilizes endogenous ECM to study how modifications associated with age and metabolic disease impact the VSMC phenotype.
R Soc Open Sci
January 2025
School of Biological Sciences, University of Bristol, Bristol, UK.
Field studies of social behaviour are challenging due to the need to record or infer interactions between multiple individuals, often under suboptimal environmental conditions or with potential disturbance by observers. Due to the limited field techniques available, we present a novel method to quantify social behaviours in the field by comparing the counts of individuals caught in traps across multiple locations sampled simultaneously. The distribution of individuals between traps gives the extent of aggregation, and phenotypic data allow for inference of non-random assortment.
View Article and Find Full Text PDFCancer Manag Res
January 2025
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Objective: Our research has pinpointed the gut microbiome's role in the progression of various pathological types of non-small cell lung cancer (NSCLC). Nonetheless, the characteristics of the gut microbiome and its metabolites across different clinical stages of NSCLC are yet to be fully understood. The current study seeks to explore the distinctive gut flora and metabolite profiles of NSCLC patients across varying TNM stages.
View Article and Find Full Text PDFQuantifying ecosystem services provided by mobile species like insectivorous bats remains a challenge, particularly in understanding where and how these services vary over space and time. Bats are known to offer valuable ecosystem services, such as mitigating insect pest damage to crops, reducing pesticide use, and reducing nuisance pest populations. However, determining where bats forage is difficult to monitor.
View Article and Find Full Text PDFFront Antibiot
May 2024
Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Ranchi, India.
Introduction: In response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Interest in identifying new chemotypes which could potentially synergize with the existing antibiotics and can be deployed as part of a combination therapy. This strategy could delay the emergence of resistance to existing antibiotics and increase their efficacy against resistant strains of mycobacterial species.
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