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A Polyketide Cyclase That Forms Medium-Ring Lactones. | LitMetric

A Polyketide Cyclase That Forms Medium-Ring Lactones.

J Am Chem Soc

State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, China.

Published: January 2021

Medium-ring lactones are synthetically challenging due to unfavorable energetics involved in cyclization. We have discovered a thioesterase enzyme DcsB, from the decarestrictine C1 () biosynthetic pathway, that efficiently performs medium-ring lactonizations. DcsB shows broad substrate promiscuity toward linear substrates that vary in lengths and substituents, and is a potential biocatalyst for lactonization. X-ray crystal structure and computational analyses provide insights into the molecular basis of catalysis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126169PMC
http://dx.doi.org/10.1021/jacs.0c11226DOI Listing

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