AI Article Synopsis
- * The study found that certain KIR genes (2DS4-003 and 2DL5) were more common in patients who died, while 2DL2 was more prevalent among survivors.
- * Logistic regression and Bayesian modeling indicated a significant association between specific KIR and HLA combinations and the outcomes of EVD, emphasizing the role of the innate immune response in fighting the virus.
Article Abstract
We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774578 | PMC |
| http://dx.doi.org/10.3201/eid2701.202177 | DOI Listing |
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