AI Article Synopsis
- This study investigated how phlorizin, a dietary supplement, affects gut microbiota balance and oxidative stress in an obesity mouse model.
- Mice were divided into groups receiving different diets, including normal chow and high-fat diets, with some receiving phlorizin, which improved lipid levels and gut health.
- The research found that antibiotics reduced phlorizin's benefits by altering gut bacteria, emphasizing the importance of a healthy microbiome for phlorizin's effectiveness in enhancing gut health and combating obesity.
Article Abstract
We explored the effects of dietary supplementation with phlorizin on redox state-related gut microbiota homeostasis in an obesity mouse model. Mice (C57BL/6J) were grouped as follows for 12 weeks: normal chow diet group (NCD), high-fat and cholesterol diet group (HFD), and treatment groups fed with HFD along with three levels of phlorizin. Phlorizin alleviated the hyperlipidemia and redox status and increased the total ccal SCFA content (1.88 ± 0.25 mg/g). Additionally, phlorizin regulated gene expression related to lipid metabolism, redox status, and cecum barrier and rebuilt gut microbiota homeostasis. After interference by antibiotics, the total phloretin content in the feces was decreased about 4-fold, and most of the health-promoting effects were abolished, indicating that phlorizin might be susceptible to microbial biotransformation and that microecology is indispensable for maintaining the redox state capacities of phlorizin. Phlorizin treatment could be an advantageous option for improving HFD-related obesity and redox states related to gut microbiota homeostasis.
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| http://dx.doi.org/10.1021/acs.jafc.0c06426 | DOI Listing |
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