AI Article Synopsis
- There is limited data on the impact of COVID-19 on kidney transplant recipients (KTRs) in emerging countries, specifically in India, where a study involved 250 patients confirmed positive for the virus.
- The study found that KTRs presented with high comorbidity rates, especially hypertension and diabetes, and exhibited a range of COVID-19 symptoms, with 14% experiencing severe disease and a mortality rate of 11.6%.
- Key risk factors for higher mortality included older age, severe disease, prior allograft dysfunction, and the need for intensive care, with significant mortality rates, particularly in ventilated patients.
Article Abstract
Background: There is a scarcity of data on the consequences of coronavirus disease-19 (COVID-19) infections in kidney transplant recipients (KTRs) from emerging countries.
Methods: Here, we present a cohort study of 13 transplant centers in India including 250 KTR (226 living and 24 deceased donors) with polymerase chain reaction-confirmed COVID-19 positivity from March 23, 2020, until September 15, 2020. We detailed demographics, immunosuppression regimen, clinical profile, treatment, and outcomes.
Results: Median age of transplant recipients was 43 years, and recipients presented at a median of 3.5 years after transplant. Most common comorbidities (94%) included arterial hypertension (84%) and diabetes (32%); presenting symptoms at the time of COVID-19 included fever (88%), cough (72%), and sputum production (52%). Clinical severity ranged from asymptomatic (6%), mild (60%), and moderate (20%) to severe (14%). Strategies to modify immunosuppressants included discontinuation of antimetabolites without changes in calcineurin inhibitors and steroids (60%). Risk factors for mortality included older age; dyspnea; severe disease; obesity; allograft dysfunction before COVID-19 infection; acute kidney injury; higher levels of inflammatory markers including C-reactive protein, interleukin-6 level, and procalcitonin; chest X-ray abnormality, and intensive care unit/ventilator requirements. Overall patient mortality was 11.6% (29 of 250), 14.5% (29 of 200) in hospitalized patients, 47% (25 of 53) in intensive care unit patients, and 96.7% (29 of 30) in patients requiring ventilation. KTRs with mild COVID-19 symptoms (n = 50) were managed as outpatients to optimize the utilization of scarce resources during the COVID-19 pandemic.
Conclusions: Mortality rates in COVID-19-positive KTR appear to be higher than those in nonimmunosuppressed patients, and high mortality was noted among those requiring intensive care and those on ventilator.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993652 | PMC |
| http://dx.doi.org/10.1097/TP.0000000000003593 | DOI Listing |
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