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Management of Pediatric Rhegmatogenous Retinal Detachment.
Semin Ophthalmol
January 2025
Wills Eye Hospital Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.
Introduction And Primary Objective: Pediatric rhegmatogenous retinal detachment (RRD) presents unique challenges in diagnosis and management. A thorough evaluation of family, medical, and ocular history is helpful, as systemic and genetic conditions can predispose children to RRD. Trauma, high myopia, and history of prematurity are also common risk factors.
View Article and Find Full Text PDFRetinal glia in myopia: current understanding and future directions.
Front Cell Dev Biol
December 2024
Department of Ophthalmology, Laboratory of Optometry and Vision Sciences, Department of Optometry and Visual Science. West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- Myopia is a significant public health issue characterized by the elongation and thinning of various eye layers, leading to blurred vision due to defocused light.
- The role of different glial cells in the retina, including astrocytes, Müller cells, and microglia, is being studied to understand their impact on myopia, particularly regarding support, response to inflammation, and mechanical stretching.
- This review highlights existing research on the involvement of retinal glia in myopia and suggests avenues for future investigations in this area.
Background: The ciliary muscle is known to play a part in presbyopia, but the mechanism has not received a comprehensive review, which this study aims to achieve. We examined relevant articles published from 1975 through 2022 that explored various properties of the muscle and related tissues in humans and rhesus monkeys. These properties include geometry, elasticity, rigidity, and composition, and were studied using a range of imaging technologies, computer models, and surgical methods.
View Article and Find Full Text PDFAn Optimized Method to Produce Human-Induced Pluripotent Stem Cell-Derived Limbal Stem Cells Easily Adaptable for Clinical Use.
Stem Cells Dev
December 2024
Cell Therapy Service, Banc de Sang i Teixits (BST), Passeig Taulat 116, 08005, Barcelona, Spain.
In adults, the limbal stem cells (LSC) reside in the limbal region of the eye, at the junction of the cornea and the sclera where they renew the outer epithelial layer of the cornea assuring transparency. LSC deficiencies (LSCD) due to disease or injury account for one of the major causes of blindness. Among current treatments for LSCD, cornea transparency can be restored by providing new LSC to the damaged eye and induced pluripotent stem cells (iPSC) holds great promise as a new advanced cell source.
View Article and Find Full Text PDFEfficacy and safety of methotrexate in the treatment of proliferative vitreoretinopathy: a systematic review.
Eye (Lond)
December 2024
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Proliferative Vitreoretinopathy (PVR) is a major complication of surgical repair for Rhegmatogenous Retinal Detachment (RRD). Methotrexate (MTX), a folate antimetabolite, has shown promise in targeting the pathological processes involved in PVR, such as cell proliferation inhibition, fibrosis and anti-inflammation. Systematic review examines the use of MTX in PVR by analysing different administration methods and outcomes.
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