Tigecycline and carbapenem are last-resort antibiotics for serious infections caused by pathogens with multi-drug resistance (MDR). Whereas, bacterial pathogens with co-resistance to tigecycline and carbapenem are poorly addressed. Here we report a tigecycline- and carbapenem-resistant Acinetobacter indicus strain HY20 of duck origin, which co-produces Tet(X5) and NDM-3. Tet(X5) is harbored by a novel plasmid pAI01 (116,992 bp long), which carries 10 antimicrobial resistance genes (AMRs), and heavy metal resistance system cobalt-zinc-cadmium (czc) gene cluster. Unlike that tet(X5) is located in the res-tet(X5)-xerD segment of plasmid, the chromosomal bla is flanked by insertion ISAba125. Collectively, our result represents an example of co-carriage of tet(X5) and bla, heightening the importance of AMR surveillance needed in poultry production.
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Emergence of novel tigecycline resistance gene tet(X5) variant in multidrug-resistant Acinetobacter indicus of swine farming environments.
Vet Microbiol
September 2023
College of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China. Electronic address:
Article Synopsis
- Antibiotic-resistant bacteria are rapidly emerging, with a new concern being the discovery of novel resistance genes, particularly tet(X) which targets tigecycline, a key treatment for multidrug-resistant infections.
- A study characterized two strains of Acinetobacter indicus resistant to tigecycline, identifying three tet(X) variants, including a new variant called Tet(X5.4) that significantly increased resistance levels in Escherichia coli.
- The ongoing rise of multidrug-resistant bacteria and their resistance genes is a pressing global health concern that requires immediate attention.
Coexistence and characterization of Tet(X5) and NDM-3 in the MDR-Acinetobacter indicus of duck origin.
Microb Pathog
January 2021
Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, Sichuan, 610500, China; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
Tigecycline and carbapenem are last-resort antibiotics for serious infections caused by pathogens with multi-drug resistance (MDR). Whereas, bacterial pathogens with co-resistance to tigecycline and carbapenem are poorly addressed. Here we report a tigecycline- and carbapenem-resistant Acinetobacter indicus strain HY20 of duck origin, which co-produces Tet(X5) and NDM-3.
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